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187034-31-7

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187034-31-7 Structure

187034-31-7 Structure
IdentificationBack Directory
[Name]

TAPI-2
[CAS]

187034-31-7
[Synonyms]

TAPI-2
CS-2628
TAPI2;TAPI 2
TNF Protease Inhibitor 2
TNF-ALPHA PROTEASE INHIBITOR-2
TAPI-2 (TNF Protease Inhibitor 2)
HONHCOCH2CH(CH2-CH(CH3)2)CO-T-LEU-ALA-NHCH2CH2NH2
N-(R)-(2-(HYDROXYAMINOCARBONYL)METHYL)-4-METHYLPENTANOYL-L-T-BUTYL-GLYCYL-L-ALANINE 2-AMINOETHYL AMIDE
N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-T-BUTYL-ALANYL-L-ALANINE, 2-AMINOETHYL AMIDE
N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide
L-Alaninamide, N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-
N-[2-[2-(HydroxyaMino)-2-oxoethyl]-4-Methyl-1-oxopentyl]-3-Methyl-L-valyl-N-(2-aMinoethyl)-L-alaninaMide Acetic Acid
[Molecular Formula]

C19H37N5O5
[MDL Number]

MFCD04119706
[MOL File]

187034-31-7.mol
[Molecular Weight]

415.53
Chemical PropertiesBack Directory
[density ]

1.127±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Ethanol: 5 mg/ml; Water: 8 mg/ml
[form ]

Solid
[pka]

9.17±0.20(Predicted)
[color ]

White to off-white
[Sensitive ]

Light Sensitive & Hygroscopic
Hazard InformationBack Directory
[Uses]

N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide is a TACE inhibitor. Inhibits the secretase in pig kidney microvillar membranes.
[Definition]

ChEBI: N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide Acetic Acid is a dipeptide.
[Biological Activity]

Cell permeable: no''Primary Target
MMPs''Product does not compete with ATP.''Reversible: no''Target IC50: 18 μM against angiotensin converting enzyme
[IC 50]

MMP: 20 μM (IC50)
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