| Identification | Back Directory | [Name]
Trifluoromethanesulfonic acid difluoromethyl ester | [CAS]
1885-46-7 | [Synonyms]
Difluoromethyl triflate
Difluoromethyl triflate 95%
Difluoromethyl trifluoromethanesulfonate
Difluoromethyl trifluoromethanesulfonate 95%
Trifluoromethanesulfonic acid difluoromethyl ester
Methanesulfonic acid, 1,1,1-trifluoro-, difluoromethyl ester | [Molecular Formula]
C2HF5O3S | [MDL Number]
MFCD28054469 | [MOL File]
1885-46-7.mol | [Molecular Weight]
200.08 |
| Chemical Properties | Back Directory | [Boiling point ]
48.5-49 °C | [density ]
1.584 g/mL at 25 °C | [Fp ]
57℃ | [storage temp. ]
2-8°C | [form ]
liquid | [color ]
Clear, colourless | [InChI]
InChI=1S/C2HF5O3S/c3-1(4)10-11(8,9)2(5,6)7/h1H | [InChIKey]
DAANAKGWBDWGBQ-UHFFFAOYSA-N | [SMILES]
C(F)(F)(F)S(OC(F)F)(=O)=O |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xn | [Risk Statements ]
22-34 | [Safety Statements ]
26-36/37/39-45 | [RIDADR ]
UN 2920 3(8) / PGII | [WGK Germany ]
3 | [HS Code ]
2905190098 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3
Skin Corr. 1B |
| Hazard Information | Back Directory | [Uses]
Difluoromethyl triflate (TfO-CHF2) can be used as a reagent:
- In difluoromethylation reaction.
- To prepare difluoromethoxylated heterocycles by reacting with hydroxylated N-based heterocycles.
- To synthesize trifluoromethylated arenes by treating with diaryliodonium salts in the presence of copper and tetrabutylammonium difluorotriphenylsilicate (TBAT).
It allows for a simple method toward the preparation of difluoromethyl ethers and thioethers under basic conditions from alcohols and thiols. Difluoromethyl phenols can also be obtained in a single pot from boronic acids and C-H activation of arenes. | [General Description]
Difluoromethyl triflate (HCF2OTf) is an easy to handle, air-stable and non-ozone-depleting liquid reagent for difluoromethylation. It can be prepared by reacting trifluoromethyltrimethylsilane (TMSCF3) and triflic acid in the presence of titanium tetrachloride (TiCl4). |
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SHANG FLUORO
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Sigma-Aldrich
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https://www.sigmaaldrich.cn |
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Rhawn Reagent
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Labnetwork lnc.
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