189060-98-8

Directory

189060-98-8 Structure

Identification	Back Directory
[Name] N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE
[CAS] 189060-98-8
[Synonyms] Ngb 2904 Ngb-2904 NGB2904 HCl NGB 2904 HYDROCHLORIDE N-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyl)-3-fluorenylcarboxamide N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-9H-fluorene-2-carboxamide N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide 9H-Fluorene-2-carboxamide, N-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyl)- N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE addiction,NGB 2904,orally,active,cocaine,Dopamine Receptor,dopamine,inhibit,Inhibitor,selective
[Molecular Formula] C28H29Cl2N3O
[MDL Number] MFCD09971107
[MOL File] 189060-98-8.mol
[Molecular Weight] 494.46

Chemical Properties	Back Directory
[Boiling point ] 691.0±55.0 °C(Predicted)
[density ] 1.264±0.06 g/cm3(Predicted)
[storage temp. ] Desiccate at +4°C
[solubility ] DMSO: 25 mM,Ethanol: 5 mM
[form ] Solid
[pka] 14.70±0.20(Predicted)
[color ] White to off-white

Hazard Information	Back Directory
[Uses] NGB 2904 is a highly-selective D3DR antagonist.
[Biological Activity] Potent and selective dopamine D 3 receptor antagonist (K i values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D 3 , D 2 , 5-HT 2 , α 1 , D 4 , D 1 and D 5 receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC 50 = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.
[in vivo] NGB 2904 (26 μg/kg; a single s.c.) enhances amphetamine (26 mg/kg)-stimulated locomotion in wild-type mice^[3]. NGB 2904 (0.026 μg-1 mg/kg; a single s.c. or once daily for 7 d) stimulates spontaneous locomotion in wild-type mice^[3].
[IC 50] D₃ Receptor: 1.4 nM (Ki)
[storage] Store at 2-8°C, protect from light

Spectrum Detail	Back Directory
[Spectrum Detail] N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE(189060-98-8)¹HNMR

189060-98-8 suppliers list

Company Name:	3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:	821-50328103-801 18930552037
Website:	www.chemicalbook.com/ShowSupplierProductsList13285/0_EN.htm

Company Name:	Shanghai YuanYe Biotechnology Co., Ltd.
Tel:	021-61312847; 18021002903
Website:	http://www.shyuanye.com

Company Name:	Tianjin Kailiqi Biotechnology Co., Ltd.
Tel:	15076683720
Website:	http://www.cw-bio.com

Company Name:	ShangHai Biochempartner Co.,Ltd
Tel:	177-54423994 17754423994
Website:	https://www.biochempartner.com

Company Name:	Shanghai Chaolan Chemical Technology Center
Tel:	021-QQ：65489617 15618227136
Website:	www.atkchemical.com/

Company Name:	Shanghai Dongyang Biotechnology Co., Ltd.
Tel:	0512-0512-13601744364 13601744364
Website:	www.chemicalbook.com/ShowSupplierProductsList1201937/0_EN.htm

Company Name:	ShangHai ChuanQian Chemcial Technique Centre
Tel:	15869524721
Website:	www.chemicalbook.com/ShowSupplierProductsList68594/0_EN.htm

Company Name:	Shanghai Yifei Biotechnology Co. , Ltd.
Tel:	021-65675885 18964387627
Website:	http://www.efebio.com

Company Name:	Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
Tel:	025-58851090 17714375163
Website:	https://www.aikonchem.com/

Company Name:	Sangon Biotech (Shanghai) Co.,Ltd.
Tel:	400-821-026
Website:	www.sangon.com

Company Name:	Santa Cruz Biotechnology Inc
Tel:	021-60936350
Website:	www.scbt.com

Company Name:	Shanghai Amole Biotechnology Co., Ltd.
Tel:	18916360931 18916360931
Website:	www.amole.com.cn/

Tags:189060-98-8 Related Product Information

30084-90-3 119532-26-2

HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

Login