| Identification | More | [Name]
4,5-DIFLUOROPHTHALIC ANHYDRIDE | [CAS]
18959-30-3 | [Synonyms]
4,5-DIFLUOROPHTHALIC ANHYDRIDE
4,5-DIFLUOROPHTHALIC ANHYDRIDE 98% | [EINECS(EC#)]
808-095-8 | [Molecular Formula]
C8H2F2O3 | [MDL Number]
MFCD00152992 | [Molecular Weight]
184.1 | [MOL File]
18959-30-3.mol |
| Questions And Answer | Back Directory | [Synthesis]
Step 1: Add 100g of 4,5-difluorophthalic acid and 150ml of acetic anhydride to a three-necked reaction flask, then heat to 120℃ and reflux. After reacting for 12h, stop heating and cool to room temperature. White crystals were observed to precipitate. Filter the crystals and wash with petroleum ether. The resulting gray solid, after drying, was 89g (yield 98%). ¹H NMR (CD₂Cl₂, 400MHz): δ (ppm) 7.73 (m, 2H), 3.23 (s, 2H). Step 2: Weigh 75g of the above acid anhydride and disperse it in a mixture of 500ml acetic anhydride and 250ml triethylamine. Stir at room temperature for 5 minutes, then add 40g of ethyl acetoacetate to the reaction flask and stir overnight at room temperature. Step 3: Add 810ml of 2N hydrochloric acid dropwise to the reaction system. A precipitate will be observed in the reaction system. Determine whether the reaction has reached its endpoint by observing whether carbon dioxide is released. Stop adding the acid after reaching the endpoint. Then gradually raise the temperature to 100℃ and maintain it for 2 hours. After the reaction is complete, filter, wash with water and petroleum ether, and vacuum dry to obtain 42g of product (yield 85%). |
| Chemical Properties | Back Directory | [Melting point ]
99-100℃ | [Boiling point ]
321.2±32.0 °C(Predicted) | [density ]
1.658 | [storage temp. ]
Store below +30°C. | [form ]
solid | [color ]
Gray | [InChI]
InChI=1S/C8H2F2O3/c9-5-1-3-4(2-6(5)10)8(12)13-7(3)11/h1-2H | [InChIKey]
UATBWQQFLABWKR-UHFFFAOYSA-N | [SMILES]
C1(=O)C2=C(C=C(F)C(F)=C2)C(=O)O1 | [CAS DataBase Reference]
18959-30-3(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
4,5-Difluorophthalic anhydride is a cyclo-anhydride compound with a wide range of applications in a variety of fields including chemicals, plastics, agrochemicals and pharmaceuticals. It can be reacted chemically with several nucleophiles, including thiocarbamoyl hydrazide and different amines, to produce carboxylic acid derivatives arising from anhydride open-circuit, i.e., phthalimide and dicarboxylic acid products. | [General Description]
4,5-Difluorophthalic anhydride (CPA) is located on the twofold axis of the space group C2/c; the molecules are stacked in a two-dimensional sheet. It has a similar two-dimensional molecular sheet as 5,6-dichlorobenzfurazan 1-oxide (CBF), 4,5-dibromophthalic anhydride. The disordered CBF molecule is pseudoisomeric with the CPA molecule. |
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
China Langchem Inc.
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0086-21-58956006 |
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www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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