| Identification | Back Directory | [Name]
RV521 | [CAS]
1903763-82-5 | [Synonyms]
RV521
Sisunatovir (Synonyms: RV521)
Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzimidazol-2-yl]methyl]-6'-fluoro- | [Molecular Formula]
C23H22F4N4O | [MDL Number]
MFCD31631588 | [MOL File]
1903763-82-5.mol | [Molecular Weight]
446.44 |
| Chemical Properties | Back Directory | [Boiling point ]
651.9±55.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 3.33 mg/mL (7.46 mM; Need ultrasonic) | [form ]
Solid | [pka]
8.75±0.50(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C23H22F4N4O/c24-15-3-4-16-19(11-15)31(21(32)22(16)7-8-22)13-20-29-17-10-14(12-28)2-5-18(17)30(20)9-1-6-23(25,26)27/h2-5,10-11H,1,6-9,12-13,28H2 | [InChIKey]
JOPCJJSYRPUEDS-UHFFFAOYSA-N | [SMILES]
C12(C3=C(N(CC4N(CCCC(F)(F)F)C5=CC=C(CN)C=C5N=4)C1=O)C=C(F)C=C3)CC2 |
| Hazard Information | Back Directory | [Uses]
Sisunatovir (RV521) is a potent and orally active respiratory syncytial virus (RSV) inhibitor with IC50 values of 1.4, 1.0 nM for RSV A, RSV B, respectively. Sisunatovir inhibits RSV infection and reduces virus titers in the lungs of mice[1]. | [in vivo]
Sisunatovir (0, 1, 10, 50 mg/kg; p.o.) reduces virus titers in the lungs of mice with RSV A2 infection[1]. | [storage]
Store at -20°C | [References]
[1] DeVincenzo J, et al. A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein. Antimicrob Agents Chemother. 2020;64(2):e01884-19. Published 2020 Jan 27. DOI:10.1128/AAC.01884-19 |
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Wuhan Topule
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http://www.topule.com/ |
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