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1903763-83-6

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1903763-83-6 Structure

1903763-83-6 Structure
IdentificationBack Directory
[Name]

Sisunatovir HCl
[CAS]

1903763-83-6
[Synonyms]

RV521 HCL
Sisunatovir HCl
[Molecular Formula]

C23H23ClF4N4O
[MDL Number]

MFCD34167498
[MOL File]

1903763-83-6.mol
[Molecular Weight]

482.91
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[form ]

Solid
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

Sisunatovir (RV521) hydrochloride is a potent and orally active respiratory syncytial virus (RSV) inhibitor with IC50 values of 1.4, 1.0 nM for RSV A, RSV B, respectively. Sisunatovir hydrochloride inhibits RSV infection and reduces virus titers in the lungs of mice[1].
[in vivo]

Sisunatovir hydrochloride (0, 1, 10, 50 mg/kg; p.o.) reduces virus titers in the lungs of mice with RSV A2 infection[1].

[References]

[1] DeVincenzo J, et al. A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein. Antimicrob Agents Chemother. 2020;64(2):e01884-19 DOI:10.1128/AAC.01884-19
Spectrum DetailBack Directory
[Spectrum Detail]

Sisunatovir HCl(1903763-83-6)1HNMR
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1903763-82-5 1903763-83-6 677010-34-3 1353625-73-6