| Identification | More | [Name]
2,6-Dichlorothiobenzamide | [CAS]
1918-13-4 | [Synonyms]
2,6-DICHLOROBENZENE-1-CARBOTHIOAMIDE
2,6-DICHLOROBENZENECARBOTHIOAMIDE
2,6-DICHLOROTHIOBENZAMIDE
CHLOROTHIAMIDE
CHLORTHIAMID
2,6-dichloro-benzenecarbothioamid
2,6-dichlorothio-benzamid
2,6-dichlor-thiobenzamid
chlorthiamide
chlorthioamide
chlortiamid
dcbn
prefix
sd7961
CHLORTHIAMID PESTANAL (2,6-DICHLORO-THIO
Prefix[R]
Benzenecarbothioamide, 2,6-dichloro-
chlorthiamid (bsi,iso-e)
chlortiamide (iso-f)
CHLOROTHIAMID | [EINECS(EC#)]
217-637-7 | [Molecular Formula]
C7H5Cl2NS | [MDL Number]
MFCD00053523 | [Molecular Weight]
206.09 | [MOL File]
1918-13-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
151-152°C | [Boiling point ]
320.6±52.0 °C(Predicted) | [density ]
1.4704 (rough estimate) | [refractive index ]
1.6300 (estimate) | [Fp ]
>100 °C | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
neat | [pka]
11.71±0.29(Predicted) | [color ]
White to Pale Beige | [Water Solubility ]
0.95g/L(21 ºC) | [BRN ]
1910353 | [Henry's Law Constant]
3.5×104 mol/(m3Pa) at 25℃, MacBean (2012) | [CAS DataBase Reference]
1918-13-4(CAS DataBase Reference) | [EPA Substance Registry System]
Chlorthiamid (1918-13-4) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S36:Wear suitable protective clothing . | [WGK Germany ]
1 | [RTECS ]
CV3850000 | [Hazard Note ]
Harmful | [HazardClass ]
IRRITANT | [HS Code ]
2930909899 | [Safety Profile]
Poison by ingestion and
intraperitoneal route. Moderately toxic by
skin contact. Mutation data reported. An
herbicide. When heated to decomposition it
emits very toxic fumes of Cl-, NOx, and
sox. | [Toxicity]
LD50 oral in rabbit: 300mg/kg |
| Hazard Information | Back Directory | [Description]
Chlorthiamid is an obsolete pre-emergence herbicide once used for non-selective weed control. It is moderate soluble in water and is non-volatile. It is not persistent in soil systems and considered to be moderately mobile, and so it may leach to groundwater under certain conditions. Its toxicity to flora and fauma tends to be low to moderate. It also has a low mammalian toxicity. Little information is available on chlorthiamids potential for serious adverse health effects. | [Uses]
Refer to the productμs Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support. | [Definition]
ChEBI: 2,6-dichlorothiobenzamide is a dichlorobenzene and a thiocarboxamide. It has a role as a proherbicide and an agrochemical. | [Production Methods]
Chlorthiamid is produced commercially through a synthesis involving chlorinated aromatic compounds and thiourea chemistry. The process typically begins with the chlorination of benzene derivatives to form 2,6-dichlorobenzoyl chloride, which is then reacted with ammonium thiocyanate or similar sulphur-containing reagents to introduce the thioamide functional group. This reaction yields the active compound, chlorthiamid, under controlled temperature and solvent conditions to ensure purity and yield. Once synthesised, the product is purified and formulated. | [Mechanism of action]
Systemic, absorbed by roots and leaves, acting against germinating seeds. Inhibits cell wall synthesis | [Metabolic pathway]
Twelve metabolites are isolated from either urine or
bile from either rats (11 metabolites) or goats (seven
metabolites) given single oral doses of 14C-labeled
2,6-dichlorobenzonitrile (DCBN). Five of these
metabolites are also excreted in urine from rats dosed
orally with 2,6-dichlorothiobenzamide (DCTBA) which
is an acid amide analog. All metabolites from either DCBN or DCTBA are benzonitriles with the following
ring substituents: Cl2, OH (three isomers); Cl2, (OH)2;
Cl, (OH)2; Cl, OH, SH; Cl, OH, SCH3; SOCH3, OH;
Cl2, S-(N-acetyl)cysteine; Cl, S-(N-acetyl)cysteine; Cl,
OH, S-(N-acetyl)cysteine.
The thiobenzamide moiety of DCTBA is converted
to the nitrile in all extracted urinary metabolites. No
hydrolysis of the nitrile in DCBN to either amide or an
acid is detected. Urine is the major route for excretion;
however, enterohepatic circulation occurs. | [Pesticide Type]
Herbicide |
|
| Company Name: |
Alfa Aesar
|
| Tel: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|