| Identification | More | [Name]
2,6-Dichlorobenzylamine | [CAS]
6575-27-5 | [Synonyms]
2,6-DICHLOROBENZYLAMINE
RARECHEM AL BW 0148
SALOR-INT L480827-1EA
TIMTEC-BB SBB003780
(2,6-dichlorophenyl)methanamine
2,6-Dichlorobenzylamine, 97+% | [Molecular Formula]
C7H7Cl2N | [MDL Number]
MFCD00047928 | [Molecular Weight]
176.04 | [MOL File]
6575-27-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear pale yellow liquid | [Melting point ]
40°C | [Boiling point ]
108°C/ 8mm | [density ]
1.320±0.06 g/cm3(Predicted) | [refractive index ]
1.557-1.559
| [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Liquid | [pka]
7.98±0.10(Predicted) | [color ]
Clear colorless to yellow | [Sensitive ]
Air Sensitive | [CAS DataBase Reference]
6575-27-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN2735 | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29214990 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear pale yellow liquid | [Uses]
(2,6-Dichlorophenyl)methanamine was one of the reactants used in making a library of highly selective and potent G protein-coupled receptor kinase 2 inhibitors. | [Synthesis]
The general procedure for the synthesis of 2,6-dichlorobenzaldehyde oxime as raw material for 2,6-dichlorobenzylamine was as follows: 2,6-dichlorobenzaldehyde oxime (0.121 g, 1 mmol) was mixed and milled with nano Fe3O4 (0.046 g, 0.2 mmol, particle size about 70 nm) in a porcelain mortar. Subsequently, ZrCl4 (0.233 g, 1 mmol) was added and the mixture continued to be ground at room temperature. The mortar was heated in an oil bath until the temperature of the reaction mixture reached 75-80 °C. After batchwise addition of NaBH3CN (0.314 g, 5 mmol), the reaction mixture was continued to be ground at 75-80 °C for 15 min. After the reaction was completed, H2O (5 mL) was added and stirred for 5 min. The mixture was extracted with EtOAc (2 x 5 mL), the organic phases were combined and dried with anhydrous Na2SO4. Evaporation of the solvent gave a pure 2,6-dichlorobenzylamine liquid in 93% yield (0.1 g, see Table 2, entry 1). | [References]
[1] Journal of the Iranian Chemical Society, 2015, vol. 12, # 5, p. 873 - 878
[2] Journal of Medicinal Chemistry, 1984, vol. 27, # 9, p. 1111 - 1118 |
|
|