| Identification | Back Directory | [Name]
Piperidine, 1-(2-phenoxyethyl)-4-(phenylmethyl)- | [CAS]
193354-70-0 | [Synonyms]
S1R agonist 1
Piperidine, 1-(2-phenoxyethyl)-4-(phenylmethyl)- | [Molecular Formula]
C20H25NO | [MOL File]
193354-70-0.mol | [Molecular Weight]
295.42 |
| Chemical Properties | Back Directory | [Boiling point ]
427.6±28.0 °C(Predicted) | [density ]
1.048±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
8.52±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
S1R agonist 1 (Compound 6b) is a selective S1R agonist with Kis of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1]. | [in vivo]
S1R agonist 1 (Compound 6b; 0.1-50 μM; 120 h) induces the death of 4 Zebrafish embryos out of 8 at 10 μM[1]. | [IC 50]
Sigma 1 Receptor: 0.93 nM (Ki); Sigma 2 Receptor: 72 nM (Ki) | [References]
[1] Linciano P, et al. Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents. Eur J Med Chem. 2023 Mar 5;249:115163. DOI:10.1016/j.ejmech.2023.115163 |
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| Company Name: |
Biorbyt Ltd.
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| Tel: |
+44 (0)1223 859 353 |
| Website: |
www.biorbyt.com |
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