| Identification | Back Directory | [Name]
MMP-9 Inhibitor II | [CAS]
193807-60-2 | [Synonyms]
Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor II
Benzenepropanamide, α-[([1,1'-biphenyl]-4-ylsulfonyl)amino]-N-hydroxy-, (αR)-
MMP-2/MMP-9 INHIBITOR II;MATRIX METALLOPROTEINASE-2/MATRIX METALLOPROTEINASE-9 INHIBITOR II | [Molecular Formula]
C21H20N2O4S | [MDL Number]
MFCD02683958 | [MOL File]
193807-60-2.mol | [Molecular Weight]
396.46 |
| Chemical Properties | Back Directory | [Melting point ]
169-170 °C | [density ]
1.309±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mg/ml; Methanol: 25 mg/ml | [form ]
A solid | [pka]
9.03±0.40(Predicted) | [color ]
off-white |
| Hazard Information | Back Directory | [Uses]
MMP-2/MMP-9 Inhibitor II is a potent inhibitor of MMP-2 and MMP-9. | [Biological Activity]
Cell permeable: no''Primary Target
MMP-2''Product does not compete with ATP.''Reversible: no''Target IC50: 17 nM30 nM against MMP-2and MMP-9respectively | [in vivo]
Daily oral administration of 200 mg/kg BPHA in mice results in potent inhibition of tumor-induced angiogenesis, primary tumor growth, and liver metastasis. The growth inhibition activity of BPHA is 48% and 45% in a B16-BL6 melanoma and F2 hemangio-endothelioma model, respectively[1]. | [IC 50]
MMP-2: 12 nM (IC50); MMP-9: 16 nM (IC50); MMP-14: 17 nM (IC50); MMP-1: 974 nM (IC50); MMP-3: >1000 nM (IC50); MMP-7: 795 nM (IC50) | [storage]
Store at -20°C |
|
| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|