| Identification | Back Directory | [Name]
L-Valinamide, 3-[[[[4-[[N-[4-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]amino]-N,β,β-trimethyl-L-phenylalanyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-buten-1-yl]-N,3-dimethyl- | [CAS]
1977557-97-3 | [Synonyms]
L-Valinamide, 3-[[[[4-[[N-[4-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]amino]-N,β,β-trimethyl-L-phenylalanyl-N-[(1S,2E)-3-carboxy-1-(1-methylethyl)-2-buten-1-yl]-N,3-dimethyl- | [Molecular Formula]
C65H84N10O11 | [MOL File]
1977557-97-3.mol | [Molecular Weight]
1181.42 |
| Chemical Properties | Back Directory | [Boiling point ]
1314.3±65.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.68±0.19(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SC239 is a cleavable 2-aminophenyl hemiasterlin agent-linker. SC239 can be as the agent-linker for ADC[1]. SC239 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [References]
[1] Xiaofan Li, et al. Abstract 1782: Discovery and activity of STRO-002, a novel ADC targeting folate receptor alpha for ovarian and endometrial cancer. Cancer Res (2018) 78 (13_Supplement): 1782. |
|
|