| Identification | Back Directory | [Name]
ALISOL ACETATE B | [CAS]
19865-76-0 | [Synonyms]
ALISOL ACETATE B
23-ACETATE ALISOL B
ALISOL ACETATE B USP/EP/BP
(8α,9β,14β)-23-Acetoxy-11β-hydroxy-dammar-13(17)-ene-3,24-dione
(8alpha,9beta,14beta)-23-Acetoxy-11beta-hydroxy-dammar-13(17)-ene-3,24-dione
8α,9β,14β-Dammar-13(17)-ene-3,24-dione, 11β,23-dihydroxy-, 23-acetate, (+)- (8CI) | [Molecular Formula]
C32H50O5 | [MDL Number]
MFCD00210473 | [MOL File]
19865-76-0.mol | [Molecular Weight]
514.74 |
| Chemical Properties | Back Directory | [Melting point ]
162-163 °C | [Boiling point ]
601.789±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.099±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Cryst. | [pka]
14.735±0.70(predicted) |
| Hazard Information | Back Directory | [Description]
Alisol B acetate can induce Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells, the Bax activation and translocation from the cytosol to nucleus might be a crucial response to the apoptotic effect. Alisol B acetate exhibits an antiproliferative effect in SGC7901 cells by inducing apoptosis, apoptosis of SGC7901 cells involves mitochondria-caspase and PI3K/Akt dependent pathways. | [Uses]
Alisol B acetate is a Triterpenoids product that can be isolated from the tubers of Alisma plantago-aquatica Linn.[1]. | [Definition]
ChEBI: Alisol b acetate is a triterpenoid. | [References]
[1] Xu YH, et al. Alisol B acetate induces apoptosis of SGC7901 cells via mitochondrial and phosphatidylinositol 3-kinases/Akt signaling pathways. World J Gastroenterol. 2009 Jun 21;15(23):2870-7. DOI:10.3748/wjg.15.2870 |
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