| Identification | Back Directory | [Name]
1,3-PBIT DIHYDROBROMIDE | [CAS]
200716-66-1 | [Synonyms]
1,3-PBIT DIHYDROBROMIDE
WCXGFTJSDASEPR-UHFFFAOYSA-N
PHENYLENE-1,3-BIS(ETHANE-2-ISOTHIOUREA) DIHYDROBROMIDE
S,S'-1,3-PHENYLENE-BIS(1,2-ETHANEDIYL)BIS-ISOTHIOUREA, DIHYDROBROMIDE | [Molecular Formula]
C12H19BrN4S2 | [MDL Number]
MFCD00797676 | [MOL File]
200716-66-1.mol | [Molecular Weight]
363.34 |
| Hazard Information | Back Directory | [Uses]
1,3-PBIT is a potent inhibitor of iNOS with a Ki of 47 nM compared to Ki values for eNOS and nNOS are 9 and 0.25 μM, respectively, for the purified human enzymes. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability. | [References]
[1] Garvey, et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J. Biol. Chem. 269(43), 26669-26676 (1994). |
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