| Identification | More | [Name]
2-(2-Aminoethyl)isothiourea dihydrobromide | [CAS]
56-10-0 | [Synonyms]
2-(2-AMINOETHYL)-2-THIOPSEUDO-UREA 2HBR
2-(2-AMINOETHYL)-2-THIOPSEUDOUREA DIHYDROBROMIDE
2-(2-aminoethyl)isothiourea dihydrobromide
2-AMINOETHYL CARBAMIMIDOTHIOATE, DIHYDROBROMIDE
2-AMINOETHYL IMIDOTHIOCARBAMATE DIHYDROBROMIDE
2-AMINOETHYLISOTHIOURONIUM BR
2-AMINOETHYLISOTHIOURONIUM BROMIDE
2-AMINOETHYLISOTHIOURONIUM BROMIDE HYDROBROMIDE
AET
AET, DIHYDROBROMIDE
ANTIRADON
BETA-AMINOETHYLISOTHIOURONIUM BROMIDE HYDROBROMIDE
CARBAMIMIDOTHIOIC ACID 2-AMINOETHYL ESTER DIHYDROBROMIDE
IFLAB-BB F0861-0023
NSC 22877
S-(2-AMINOETHYL)ISOTHIOUREA 2HBR
S-(2-AMINOETHYL)ISOTHIOUREA DIHYDROBROMIDE
S-(2-AMINOETHYL)ISOTHIOURONIUM BROMIDE HYDROBROMIDE
S-(2-AMINOETHYL)ISOTHIOURONIUM HYDROGEN-BROMIDE
S(-2-AMINOETHYL)-ITU DIHYDROBROMIDE | [EINECS(EC#)]
200-257-0 | [Molecular Formula]
C3H11Br2N3S | [MDL Number]
MFCD00037011 | [Molecular Weight]
281.01 | [MOL File]
56-10-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
190-196 °C(lit.)
| [density ]
1.94 g/cm3 | [storage temp. ]
Store below +30°C. | [solubility ]
50g/l | [form ]
powder to crystal | [color ]
White to Almost white | [Water Solubility ]
almost transparency | [Merck ]
14,178 | [BRN ]
3911163 | [InChI]
InChI=1S/C3H9N3S.2BrH/c4-1-2-7-3(5)6;;/h1-2,4H2,(H3,5,6);2*1H | [InChIKey]
XDVMCVGTDUKDHL-UHFFFAOYSA-N | [SMILES]
S(CCN)C(=N)N.Br.Br | [CAS DataBase Reference]
56-10-0(CAS DataBase Reference) | [EPA Substance Registry System]
56-10-0(EPA Substance) |
| Questions And Answer | Back Directory | [?Synthesis]
Ethylamine thiourea is synthesized by using cycloethylamine, hydrobromic acid and thiourea as raw materials: firstly, thiourea is mixed with hydrogen bromide acid, and cycloethylamine is added dropwise at a temperature below 150 °C. After the reaction is completed, add activated carbon to filter, and then reduce Dehydration under pressure, crystals are precipitated when the temperature is below 50°C, filtered, and washed twice with absolute ethanol. |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S22:Do not breathe dust . | [WGK Germany ]
3
| [RTECS ]
UM0175000
| [F ]
10-21 | [TSCA ]
Yes | [HS Code ]
2930 90 98 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | [Toxicity]
LD50 in mice (mg/kg): 100 i.v., 280 s.c., 480 i.p., 1600 orally (Pospisil) |
| Hazard Information | Back Directory | [Description]
S-(2-aminoethyl) Isothiourea is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 μM, respectively.1 | [Chemical Properties]
Crystals, hygroscopic. | [Uses]
NOS inhibitor | [in vivo]
AE-ITU dihydrobromide (1 mg/kg/h, i.v., for 1 hour) attenuates the delayed hypotension and vascular hyporeactivity, ameliorates liver dysfunction in LPS (HY-D1056)-administrated Wistar rats[1]. | Animal Model: | LPS (HY-D1056)-administrated Wistar rats[1] | | Dosage: | 1 mg/kg | | Administration: | i.v., 1 mg/kg/h for 1 hour | | Result: | Reduced the serum levels of bilirubin, serum nitrite, GOT, GPT and γGT caused by LPS, inhibited iNOS in lung and liver homogenates. |
| [IC 50]
iNOS | [Purification Methods]
Crystallise the salt from absolute EtOH/ethyl acetate or MeOH. Store dry as it is hygroscopic in a humid atmosphere. It is a radioprotective agent. When refluxed in EtOH for 16hours or H2O for 30minutes, it decomposes to 2-amino-4(5H)-thiazoline hydrobromide which on recrystallisation from isoPrOH/EtOAc has m 175-176o [Doherty et al. J Am Chem Soc 79 5667 1957]. | [References]
[1]. garvey ep, oplinger ja, tanoury gj, et al. potent and selective inhibition of human nitric oxide synthases. inhibition by non-amino acid isothioureas. j biol chem. 1994 oct 28;269(43):26669-76. |
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