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2022182-58-5

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2022182-58-5 Structure

2022182-58-5 Structure
IdentificationBack Directory
[Name]

Thalidomide-O-amido-C3-NH2 (TFA)
[CAS]

2022182-58-5
[Synonyms]

Thalidomide-O-amido-C3-NH2
Thalidomide-O-amido-C3-NH2 (TFA)
Pomalidomide Related Compound 3 Triflate
Cereblon Ligand-Linker Conjugates 16 TFA
E3 Ligase Ligand-Linker Conjugates 52 (TFA)
N-(3-aminopropyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
N-(3-aminopropyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide(TFA)
N-(3-Aminopropyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide 2,2,2-trifluoroacetate
N-(3-Aminopropyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide trifluoroacetic acid salt
[Molecular Formula]

C20H21F3N4O8
[MDL Number]

MFCD32215305
[MOL File]

2022182-58-5.mol
[Molecular Weight]

502.4
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Thalidomide-O-amido-C3-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
[IC 50]

Cereblon
[References]

[1] Lohbeck J, et al. Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5260-5262. DOI:10.1016/j.bmcl.2016.09.048
Spectrum DetailBack Directory
[Spectrum Detail]

Thalidomide-O-amido-C3-NH2 (TFA)(2022182-58-5)1HNMR
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