2028284-73-1

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2028284-73-1 Structure

Identification	Back Directory
[Name] Tos-PEG5-CH2CO2H
[CAS] 2028284-73-1
[Synonyms] Tos-PEG5-CH2CO2H Tos-PEG4-CH2COOH Tos-PEG5-CH2COOH Acetic acid, 2-[2-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-
[Molecular Formula] C17H26O9S
[MDL Number] MFCD30458013
[MOL File] 2028284-73-1.mol
[Molecular Weight] 406.45

Hazard Information	Back Directory
[Description] Tos-PEG5-CH2CO2H is a PEG linker containing a tosyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
[Uses] Tos-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50] PEGs
[References] [1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6

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