| Identification | Back Directory | [Name]
2-Bromo-6-nitrobenzaldehyde | [CAS]
20357-21-5 | [Synonyms]
100117
2-Bromo-6-nitrobenzaldehyde
Benzaldehyde, 2-broMo-6-nitro-
2-Bromo-6-nitrobenzaldehyde 98%
2-Bromo-6-Nitrobenzaldehyde,>98% | [Molecular Formula]
C7H4BrNO3 | [MDL Number]
MFCD09040530 | [MOL File]
20357-21-5.mol | [Molecular Weight]
230.02 |
| Chemical Properties | Back Directory | [Melting point ]
86-87°C | [Boiling point ]
320.8±27.0 °C(Predicted) | [density ]
1.781 | [refractive index ]
1.653 | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
solid | [color ]
Yellow | [InChI]
InChI=1S/C7H4BrNO3/c8-6-2-1-3-7(9(11)12)5(6)4-10/h1-4H | [InChIKey]
WRIAMYXQKSDDRP-UHFFFAOYSA-N | [SMILES]
C(=O)C1=C([N+]([O-])=O)C=CC=C1Br |
| Hazard Information | Back Directory | [Uses]
2-Bromo-6-nitrobenzaldehyde is mainly used as an intermediate in organic synthesis, especially in the production of drugs and dyes. | [Synthesis]
N-Bromosuccinimide (NBS) (1.48 g, 8.32 mmol) was added to a solution of 2-Nitrobenzaldehyde (1.01 g, 6.71 mmol) in H2SO4 (concentrated 5.0 mL). The resulting mixture was stirred at ambient temperature (3 h). The reaction was quenched with ice and extracted with ethyl acetate (320mL). The combined organic phases were washed with saturated NaCl (aqueous, 30 mL), dried (MgSO4), and filtered through a silica gel plug, and the solvents were evaporated under reduced pressure. The resulting brown oil was purified by column chromatography (hexanes=EtOAc, 8:2) to afford 2-Bromo-6-nitrobenzaldehyde.
| [References]
[1] Patent: WO2008/156656, 2008, A2. Location in patent: Page/Page column 58; 66; 120 |
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