| Identification | Back Directory | [Name]
16α-Methyl-11-oxo Prednisolone | [CAS]
2036-77-3 | [Synonyms]
DMS-0
Dexamethasone imp J
Carbamazepine Impurity 26
Dexamethasone EP Impurity J
(8S,9S,10R,13S,14S,16R,17R)
16α-Methyl-11-oxo Prednisolone
16Alpha-Methyl-11-oxo Prednisolone
Tobramycin and dexamethasone impurity J
Dexamethasone impurity 4/Dexamethasone EP Impurity J
Dexamethasone Impurity 10(Dexamethasone EP Impurity J)
17,21-dihydroxy-16α-methylpregna-1,4-diene-3,11,20-trione
17,21-Dihydroxy-16alpha-methylpregna-1,4-diene-3,11,20-trione
Dexamethasone EP Impurity J (9-desfluoro-11-keto dexamethasone )
Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16α)-
(8S,9S,10R,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8S,9S,10R,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthrene-3,11(6H)-dione
(8S,9S,10R,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthrene-3,11(6H)-dione (Dexamethasone Impurity） | [Molecular Formula]
C22H28O5 | [MDL Number]
MFCD31563183 | [MOL File]
2036-77-3.mol | [Molecular Weight]
372.455 |
| Chemical Properties | Back Directory | [Melting point ]
197-199°C | [Boiling point ]
574.4±50.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
12.38±0.70(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
A 16α-substituted Prednisolone as potent topical antiinflammatory agent. | [Synthesis]
1) Add 5.0 g of pregnane-1,4,16-triene-3,11,20-trione (compound (I-1)) with 0.02 times copper bromide dimethyl sulfide, 1.2 times trimethylchlorosilane, 2 times hexamethylphosphorotriamine to 60 ml of tetrahydrofuran, and slowly add 1.2 times methylmagnes |
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www.bocsci.com |
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