| Identification | Back Directory | [Name]
2 H-1,3-BENZOXAZINE-2,4(3 H)-DIONE | [CAS]
2037-95-8 | [Synonyms]
ruhmal
beaprine
carsalam
Carsalame
Two ketone
4(3 H)-DIONE
CAS:2037-95-8
3-BENZOXAZINE-2
oxophenhydroxazine
TIMTEC-BB SBB003929
Carsalam≥ 99% (HPLC)
Carbonylsalicylamide
1,3-BENZOXAZINE-2,4-DIONE
1,3-benzoxazine-2,4-quinone
1,3-Benzoxazine-2,4-(3H)-dione
2 H-1,3-BENZOXAZINE-2,4(3 H)-DIONE
2H-1,3-Benzoxazine-2,4(3H)-dione 98%
2H-Benzo[e][1,3]oxazine-2,4(3H)-dione
2,4-Dioxo-3,4-dihydro-2H-1,3-benzoxazine
3,4-dihydro-2H-1,3-benzoxazine-2,4-dione
CarsalaM (1,3-benzoxazine-2,4-(3H)-dione)
2 H-1,3-BENZOXAZINE-2,4(3 H)-DIONE ISO 9001：2015 REACH | [EINECS(EC#)]
606-541-4 | [Molecular Formula]
C8H5NO3 | [MDL Number]
MFCD00600566 | [MOL File]
2037-95-8.mol | [Molecular Weight]
163.13 |
| Chemical Properties | Back Directory | [Melting point ]
228-232 °C(lit.) | [density ]
1.402±0.06 g/cm3(Predicted) | [vapor pressure ]
0.73-1.27Pa at 89.94-107.94℃ | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO : ≥ 40 mg/mL (245.20 mM) | [form ]
Solid | [pka]
9.16±0.20(Predicted) | [color ]
White to off-white | [Merck ]
13,1879 | [InChI]
InChI=1S/C8H5NO3/c10-7-5-3-1-2-4-6(5)12-8(11)9-7/h1-4H,(H,9,10,11) | [InChIKey]
OAYRYNVEFFWSHK-UHFFFAOYSA-N | [SMILES]
O1C2=CC=CC=C2C(=O)NC1=O | [LogP]
0.78-0.88 at 20℃ |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302 | [Precautionary statements ]
P280-P305+P351+P338 | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [Safety Statements ]
36 | [WGK Germany ]
3 | [RTECS ]
DM3110000 | [REACH Registrations]
Active | [HS Code ]
2934999090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white to light brown crystalline powder | [Uses]
analgesic | [Definition]
ChEBI: Carsalam is a benzoxazine. | [General Description]
Kinetic studies of the alkaline hydrolysis of 2H-1,3-benzoxazine-2,4(3H)-dione (carsalam) were conducted and reaction was found to be of fractional order with respect to [OH-]. | [Synthesis]
2H-1,3-Benzoxazine-2,4(3H)-dione was prepared according to the procedure of Hoback, Crum and Carroll. To a solution of 411 g. (3. 0 moles) salicylamide in 483 ml. (6.0 moles) of anhydrous pyridine at 0℃ was added slowly with stirring 572 ml. (6.0 moles) of ethyl chlorocarbonate. The resulting orange solution was refluxed for 5 hr. and poured into 2L of ice water. The filtered product was washed twice with 0.5L of water and recrystallized three times from acetone-ethanol (50: 50), giving white needles 2H-1,3-Benzoxazine-2,4(3H)-dione (83% yield), m.p. 227.5-228.5° (lit. 12), m.p. 227-228°, which gave no coloration with ethanolic ferric chloride[1]. | [References]
[1] J. D. Crum, J. A. Franks Jr. “The chemistry of heterocycles. III. 2H-1,3-benzoxazine-2,4(3H)-dione and Some 3-substituted derivatives.??.” Journal of Heterocyclic Chemistry 2 1 (1965): 37–40.
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