| Identification | Back Directory | [Name]
Azido-PEG3-Sulfone-PEG4-t-butyl ester | [CAS]
2055023-76-0 | [Synonyms]
Azido-PEG3-Sulfone-PEG4-Boc
Azido-PEG3-Sulfone-PEG4-t-butyl ester | [Molecular Formula]
C23H45N3O11S | [MDL Number]
MFCD30182053 | [MOL File]
2055023-76-0.mol | [Molecular Weight]
571.682 |
| Hazard Information | Back Directory | [Description]
Azido-PEG3-Sulfone-PEG4-t-butyl ester is a PEG linker containing one azide group and one t-butyl protected carboxyl group. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions. | [Uses]
Azido-PEG3-Sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-Sulfone-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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