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2055896-77-8

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2055896-77-8 Structure

2055896-77-8 Structure
IdentificationBack Directory
[Name]

MC-Val-Cit-PAB-Auristatin E
[CAS]

2055896-77-8
[Synonyms]

MC-Val-Cit-PAB-Auristatin E
[Molecular Formula]

C68H108N11O13+
[MDL Number]

MFCD32197310
[MOL File]

2055896-77-8.mol
[Molecular Weight]

1287.68
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

MC-Val-Cit-PAB-Auristatin E is a agent-linker conjugate for ADC with potent antitumor activity by using Auristatin E (a cytotoxic tubulin modifier), linked via the ADC linker MC-Val-Cit-PAB.
[IC 50]

Auristatin
[References]

[1] Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119. DOI:10.1038/nchem.2635
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