| Identification | Back Directory | [Name]
SODIUM CHOLATE HYDRATE, BIOCHEMIKA, >= 9 | [CAS]
206986-87-0 | [Synonyms]
Sodium cholate hydrate
Cholic aicd sodiuM Salt
Cholalic acid sodium salt
SODIUM CHOLATE HYDRATE, 98 %
Sodium cholate hydrate, 99.5%
Cholic aicd sodium Salt hydrate
SODIUM CHOLATE HYDRATE, SIGMAULTRA
SODIUM CHOLATE HYDRATE, BIOCHEMIKA
3,7,12-trihydroxy-, monosodium salt
SODIUM CHOLATE HYDRATE BIOXTRA, >= 9
SODIUM CHOLATE HYDRATE, >= 97.0 % NT
SODIUM CHOLATE HYDRATE, FROM OX AND/
SODIUM CHOLATE HYDRATE, BIOCHEMIKA, >= 9
SODIUM CHOLATE HYDRATE, CELL CULTURE TESTED
SODIUM CHOLATE HYDRATE FROM OX OR SHEEP BILE
α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt
3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt
SODIUM CHOLATE HYDRATE, PURUM, >= 97.0% NT DRIED MATERIAL
3α,7α,12α-Trihydroxy-5β-cholanic acid sodium salt hydrate
SODIUM CHOLATE HYDRATE, BIOCHEMIKA, >= 96.0% NT DRY MATTER
Cholalic acid sodium salt, 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt
(3alpha,5alpha,7alpha,12alpha)-3,7,12-Trihydroxycholan-24-oic acid monosodium salt hydrate
Sodium cholate hydrate,3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt, Cholalic acid sodium salt
sodium,(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate,hydrate | [EINECS(EC#)]
206-643-5 | [Molecular Formula]
C24H39O5.Na | [MDL Number]
MFCD00064138 | [MOL File]
206986-87-0.mol | [Molecular Weight]
430.56 |
| Chemical Properties | Back Directory | [RTECS ]
FZ9600000 | [storage temp. ]
Store at RT. | [solubility ]
H2O: 0.1 M, clear
| [form ]
Powder | [color ]
White | [biological source]
bovine bile
ovine bile | [Optical Rotation]
[α]20/D +36±2°, c = 0.6% in ethanol (dry matter) | [Water Solubility ]
Soluble in water. | [BRN ]
3582354 | [Hydrophilic-Lipophilic Balance (HLB)]
18 | [InChIKey]
WPVYVBXDAUNXSZ-WQYDRJRFNA-N | [SMILES]
O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H303 | [Precautionary statements ]
P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 | [Safety Statements ]
24/25 | [WGK Germany ]
3
| [F ]
3-9 | [TSCA ]
Yes | [HS Code ]
29181990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Chronic 3 |
| Hazard Information | Back Directory | [Uses]
Biochemical solubilizing agent Sodium cholate hydrate is a non-denaturing detergent used for the extraction of membrane proteins. It is involved in the study to assess infiltration of pressurized promoter solutions in a mesoporous silica. Further, it serves as a biochemical solubilizing agent. | [Uses]
Cholate is a bile acid produced in liver during cholesterol breakdown. Cholate downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis). Cholate, an anionic detergent, is used alone and in combination with urea to extract and reconstitute membrane proteins and protein complexes. | [Uses]
Non-denaturing detergent used for extraction of membrane proteins. | [General Description]
Sodium cholate hydrate is a non-denaturing, anionic detergent. | [Biochem/physiol Actions]
Reduction in 12-α hydroxylase activity leads to low levels of cholic acid in liver disease. | [in vivo]
Cholic acid (1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity[2]. | Animal Model: | Tg-CYP2D6 adult male mice (8 weeks of age and weighing 20–25 g)[2] | | Dosage: | 1% (w/w) Cholic acid-supplemented diet | | Administration: | Oral, 14 days | | Result: | Decreases SHP expression and increased CYP2D6 activity. |
| [IC 50]
Human Endogenous Metabolite |
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| Company Name: |
Henan yingchuang Gold
|
| Telephone: |
16650708709 |
| Website: |
www.hnyingchuang.com/ |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|