| Identification | More | [Name]
Taurodeoxycholic acid sodium salt | [CAS]
1180-95-6 | [Synonyms]
2-[(3ALPHA,12ALPHA-DIHYDROXY-24-OXO-5BETA-CHOLAN-24-YL)-AMINO] ETHANESULFONIC ACID SODIUM SALT
3ALPHA,12ALPHA-DIHYDROXY-5BETA-CHOLAN-24-OIC ACID N-[2-SULFOETHYL]AMIDE SODIUM SALT
5BETA-CHOLANIC ACID-3ALPHA,12ALPHA-DIOL 24-N-(2-SULFOETHYL)-AMIDE SODIUM
5-BETA-CHOLANIC ACID-3-ALPHA, 12-ALPHA-DIOL N-(2-SULPHOETHYL)-AMIDE SODIUM SALT
SODIUM TAURODEOXYCHOLATE
SODIUM TAURODEOXYCHOLATE SODIUM SALT
SODIUM TAURODESOXYCHOLATE SODIUM SALT
TAURODEOXYCHOLIC ACID SODIUM
TAURODEOXYCHOLIC ACID SODIUM SALT
Taurodeoxycholic acid sodium salt hydrate
sodium 2-[[(3alpha,5beta,12alpha)-3,12-dihydroxy-24-oxocholan-24-yl]amino]ethane-1-sulphonate
Ethanesulfonic acid, 2-(3.alpha.,5.beta.,12.alpha.)-3,12-dihydroxy-24-oxocholan-24-ylamino-, monosodium salt
sodium taurodeoxylate
Sodium 2-[[(3a,5b,12a)-3,12-dihydroxy-24-oxocholan-24-yl]amino]ethane-1-sulphonate
SODIUM TAUROUSODEOXYCHOLATE
Cholane, ethanesulfonic acid deriv.
Sodium deoxytaurocholate
Sodium taurodesoxycholate
Taurodeoxycholate sodium
Taurodeoxycholic acid sodium salt hydrate,97% | [EINECS(EC#)]
214-652-0 | [Molecular Formula]
C26H44NNaO6S | [MDL Number]
MFCD00003671 | [Molecular Weight]
521.69 | [MOL File]
1180-95-6.mol |
| Chemical Properties | Back Directory | [Appearance]
white to almost white crystalline powder | [Melting point ]
168 °C (dec.)(lit.)
| [alpha ]
33 º (c=3, water) | [storage temp. ]
Freezer (-20°C) | [solubility ]
H2O: 0.5 M at 20 °C, clear, colorless to faintly yellow
| [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
soluble | [InChIKey]
YXHRQQJFKOHLAP-UROAIUCXNA-M | [CAS DataBase Reference]
1180-95-6(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
white to almost white crystalline powder | [Uses]
Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling. | [Purification Methods]
The Na salt is dissolved in the smallest volume of H2O, a saturated solution of aqueous NaCl/Et2O is added and the mixture is stored at 0o for 24hours. Then shake the mixture well, keep it in the cold for another day and filter the crystals with gentle shaking, wash them with ice-cold saturated aqueous NaCl saturated with Et2O, dry them over CaCl2 and extract them with absolute EtOH. Add ~10mL of H2O to the solid followed by enough Et2O to incipient cloudiness. Store it overnight at 0o. Add ice-cold Et2O to make 250mL, collect the crystals, wash them with Et2O then pet ether and dry them in air. The purification can be repeated with NaCl and Et2O with ~85% recovery. NB: precipitation will not occur unless enough H2O is present. Its solubility in H2O is 10%. [Cortese J Am Chem Soc 59 2532 1937.] The free acid has m 141-144o. [Norman Ark Kemi 8 331 1956.] It forms mixed micelles and solubilises some membrane proteins [Hajjar et al. J Biol Chem 2 5 8 192 1983]. [Beilstein 10 IV 1611.] |
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