| Identification | Back Directory | [Name]
2'-C-Methylcytidine | [CAS]
20724-73-6 | [Synonyms]
NM-107
2''-METHYLCYTIDINE
2'-C-METHYLCYTIDINE
2'-CMethyl-D-cytidine
2'-C-Methyl-1-β-D-ribofuranosylcytosine
1-(2-C-Methyl-β-D-ribofuranosyl)cytosine | [EINECS(EC#)]
200-001-2 | [Molecular Formula]
C10H15N3O5 | [MDL Number]
MFCD02682947 | [MOL File]
20724-73-6.mol | [Molecular Weight]
257.24 |
| Chemical Properties | Back Directory | [Appearance]
White to Off-White Powder | [Melting point ]
243-245°C | [Boiling point ]
523.9±60.0 °C(Predicted) | [density ]
1.72±0.1 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under Inert Atmosphere | [solubility ]
H2O: >20mg/mL | [form ]
powder | [pka]
13.53±0.70(Predicted) | [color ]
white to off-white | [InChIKey]
PPUDLEUZKVJXSZ-VPCXQMTMSA-N |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Powder | [Description]
2''-C-Methylcytidine (2CMC) is a ribonucleoside with broad-spectrum antiviral activity.1 It reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses with EC50 values of 95, 26, 80, and 75 μM, respectively. 2CMC inhibits hepatitis C virus (HCV) replication (EC50 = 2.2 μM in a replicon assay) and protects MDBK cells from infection with bovine virus diarrhea virus (BVDV; EC50 = 2.2 μM) and human coronavirus (HCoV; EC50 = 90 μM). It also reduces infectious virus yield in BHK-21 cells infected with foot-and-mouth disease virus (FMDV; EC50 = 6.4 μM) and swine vesicular disease virus (SVDV; EC50 = 45.2 μM).2 In vivo, 2CMC reduces viral shedding to undetectable levels in a mouse model of persistent norovirus infection.3 | [Uses]
2’-C-Methyl Cytidine (cas# 20724-73-6) is a compound useful in organic synthesis. | [Biochem/physiol Actions]
2′-C-Methylcytidine is a potent inhibitor of the HCV NS5B RNA polymerase. 2′-C-Methylcytidine was the first nucleoside NS5B inhibitor that showed clinical efficacy. 2′-C-Methylcytidine was found to be effective against the 17D vaccine strain of yellow fever virus YFV in cell culture. |
|
|