| Identification | Back Directory | [Name]
3-Pyridinecarbonitrile, 6-[(1Z)-2-[3-[(1S,5S,6S)-3-amino-5-methyl-1-(4-morpholinylcarbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-1-fluoroethenyl]- | [CAS]
2079945-75-6 | [Synonyms]
BACE1-IN-6
3-Pyridinecarbonitrile, 6-[(1Z)-2-[3-[(1S,5S,6S)-3-amino-5-methyl-1-(4-morpholinylcarbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-1-fluoroethenyl]- | [Molecular Formula]
C25H23F2N5O2S | [MOL File]
2079945-75-6.mol | [Molecular Weight]
495.54 |
| Hazard Information | Back Directory | [Uses]
BACE1-IN-6 is a BACE1 inhibitor with an IC50 value of 1.5 nM. | [References]
[1] Frohn M, et al. The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement. Bioorg Med Chem Lett. 2020 Jul 15;30(14):127240. DOI:10.1016/j.bmcl.2020.127240 |
|
|