| Identification | Back Directory | [Name]
Benzonitrile, 4-[4-[(1R)-3-(5,6-dihydro-5-oxo-1,6-naphthyridin-7-yl)-2-cyclopenten-1-yl]-1-piperazinyl]- | [CAS]
2084112-75-2 | [Synonyms]
PARP1-IN-7
Benzonitrile, 4-[4-[(1R)-3-(5,6-dihydro-5-oxo-1,6-naphthyridin-7-yl)-2-cyclopenten-1-yl]-1-piperazinyl]- | [Molecular Formula]
C24H23N5O | [MOL File]
2084112-75-2.mol | [Molecular Weight]
397.47 |
| Chemical Properties | Back Directory | [Boiling point ]
701.8±60.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
10.85±0.40(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
PARP1-IN-7 is an inhibitor of poly(ADP-ribose) polymerase-1 (PARP1) as an anticancer agent. | [References]
[1] Karche NP, et al. Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization. Bioorg Med Chem. 2020 Dec 15;28(24):115819. DOI:10.1016/j.bmc.2020.115819 |
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