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2089227-65-4

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2089227-65-4 Structure

2089227-65-4 Structure
IdentificationBack Directory
[Name]

VBIT-12
[CAS]

2089227-65-4
[Synonyms]

VBIT-12
Glycine, N-[[1-(1-naphthalenylmethyl)-4-(phenylamino)-4-piperidinyl]carbonyl]-
[EINECS(EC#)]

604-604-1
[Molecular Formula]

C25H27N3O3
[MOL File]

2089227-65-4.mol
[Molecular Weight]

417.5
Chemical PropertiesBack Directory
[Boiling point ]

698.0±55.0 °C(Predicted)
[density ]

1.286±0.06 g/cm3(Predicted)
[solubility ]

DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 15 mg/ml
[form ]

A crystalline solid
[pka]

3.65±0.10(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)Environment (GHS09)
GHS07,GHS09
[Signal word ]

Warning
Hazard InformationBack Directory
[Uses]

VBIT-12 is a potent VDAC1 inhibitor. VBIT-12 directly interacts with VDAC1 and prevents VDAC1 oligomerization, and thus inhibits apoptotic action of VDAC1[1].
[References]

[1] Shoshan-Barmatz V, et al. VDAC1, mitochondrial dysfunction, and Alzheimer's disease. Pharmacol Res. 2018 May;131:87-101. DOI:10.1016/j.phrs.2018.03.010
Spectrum DetailBack Directory
[Spectrum Detail]

VBIT-12(2089227-65-4)1HNMR
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