| Identification | Back Directory | [Name]
VBIT-12 | [CAS]
2089227-65-4 | [Synonyms]
VBIT-12
Glycine, N-[[1-(1-naphthalenylmethyl)-4-(phenylamino)-4-piperidinyl]carbonyl]- | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C25H27N3O3 | [MOL File]
2089227-65-4.mol | [Molecular Weight]
417.5 |
| Chemical Properties | Back Directory | [Boiling point ]
698.0±55.0 °C(Predicted) | [density ]
1.286±0.06 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 15 mg/ml | [form ]
A crystalline solid | [pka]
3.65±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
VBIT-12 is a potent VDAC1 inhibitor. VBIT-12 directly interacts with VDAC1 and prevents VDAC1 oligomerization, and thus inhibits apoptotic action of VDAC1[1]. | [References]
[1] Shoshan-Barmatz V, et al. VDAC1, mitochondrial dysfunction, and Alzheimer's disease. Pharmacol Res. 2018 May;131:87-101. DOI:10.1016/j.phrs.2018.03.010 |
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Twochem Co.Ltd
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021-021-58111628 15800915896 |
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www.twochem.com |
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cjbscvictory
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13348960310 |
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https://www.weikeqi-biotech.com/ |
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