| Identification | Back Directory | [Name]
Beta-mangostin | [CAS]
20931-37-7 | [Synonyms]
Β-MANGOSTIN
β-Mangostin
Beta-mangostin
shanzhuguoduofen
MANGOSTIN, BETA-
beta-Mangostin, >98%
Beta-mangostin USP/EP/BP
Keywords Dianthus extract
Beta-mangostin
β-Mangostin
Beta-mangostin
β-Mangostin
β-Mangostin, 98%, from Garcinia mangostana L.
1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-en-1-yl)-9...
1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one
1,6-Dihydroxy-3,7-dimethoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one
1,6-Dihydroxy-3,7-dimethoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
1,6-Dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
9H-Xanthen-9-one, 1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methyl-2-buten-1-yl)- | [EINECS(EC#)]
618-347-7 | [Molecular Formula]
C25H28O6 | [MDL Number]
MFCD00951751 | [MOL File]
20931-37-7.mol | [Molecular Weight]
424.49 |
| Chemical Properties | Back Directory | [Melting point ]
175-176℃ | [Boiling point ]
616.5±55.0 °C(Predicted) | [density ]
1.212 | [storage temp. ]
2-8°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
7.05±0.20(Predicted) | [color ]
Yellow | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Description]
β-Mangostin is a xanthone originally isolated from G. mangostana with diverse biological activites.1,2,3,4,5,6 It inhibits growth of methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA; MICs = 6.25-12.5 and 6.25-25 μg/ml, respectively), P. falciparum (IC50 = 3 μg/ml), and M. tuberculosis (MIC = 6.25 μg/ml).1,2,3 β-Mangostin inhibits fatty acid synthase (FASN) with an IC50 value of 24.83 μM.4 It induces cell cycle arrest at the G2/M phase and intrinsic and mitochondrial apoptosis in MCF-7 breast cancer cells.5 β-Mangostin also inhibits LPS-induced nitric oxide and prostaglandin E2 (PGE2; Item No. 14010) production in RAW264.7 cells and reduces neutrophil infiltration and TNF-α and IL-1β production in a mouse model of carrageenan-induced peritonitis.6 | [Uses]
β-Mangostin is isolated from the stem bark of Garcinia mangostana L. which shows significant cytotoxicities and anti-inflammatory activities against the LPS-induced RAW cell 264.7. Also, it demonstrates anti-metastatic activity against human hepatocellular carcinoma (HCC) cells, which may act as a promising therapeutic agent for the treatment of HCC. | [Definition]
ChEBI: Beta-Mangostin is a member of xanthones. | [IC 50]
Plasmodium | [References]
[1] MUNEKAZU IINUMA. Antibacterial Activity of Xanthones from Guttiferaeous Plants against Methicillin-resistant Staphylococcus aureus[J]. Journal of Pharmacy and Pharmacology, 1996, 48 8: 861-865. DOI: 10.1111/j.2042-7158.1996.tb03988.x
[2] K LIKHITWITAYAWUID J K T Phadungcharoen. Antimalarial xanthones from Garcinia cowa.[J]. Planta medica, 1998, 64 1: 70-72. DOI: 10.1055/s-2006-957370
[3] SUNIT SUKSAMRARN. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.[J]. Chemical & pharmaceutical bulletin, 2003, 51 7: 857-859. DOI: 10.1248/cpb.51.857
[4] HE ZHONG JIANG . Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20 20: Pages 6045-6047. DOI: 10.1016/j.bmcl.2010.08.061
[5] SUVITHA SYAM . β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells[J]. Journal of Functional Foods, 2014, 6: Pages 290-304. DOI: 10.1016/j.jff.2013.10.018
[6] SUVITHA SYAM . β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo[J]. Journal of ethnopharmacology, 2014, 153 2: Pages 435-445. DOI: 10.1016/j.jep.2014.02.051 |
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