| Identification | Back Directory | [Name]
t-Boc-Aminooxy-PEG2-CH2CO2H | [CAS]
2098983-14-1 | [Synonyms]
Boc-Aminooxy-PEG2-CH2COOH
t-Boc-Aminooxy-PEG2-CH2CO2H
3,6,9-Trioxa-2-azaundecanedioic acid, 1-(1,1-dimethylethyl) ester | [Molecular Formula]
C11H21NO7 | [MDL Number]
MFCD30730369 | [MOL File]
2098983-14-1.mol | [Molecular Weight]
279.29 |
| Hazard Information | Back Directory | [Description]
t-Boc-Aminooxy-PEG2-CH2CO2H is a short PEG linker. The terminal carboxylic acid cis reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc-protected amine can be deprotected under mild acidic conditions. | [Uses]
Boc-Aminooxy-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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