| Identification | Back Directory | [Name]
FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID | [CAS]
882847-32-7 | [Synonyms]
FmocNH-P5-COOH
Fmoc-NH-PEG5-COOH
Fmoc-amino-PEG5-acid
Fmoc-PEG5-CH2CH2COOH
Fmoc-N-amido-PEG5-acid
FMoc-NH-PEG5-CH2CH2COOH
Fmoc-PEG5-propionic acid
FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azadocosan-22-oic acid
5,8,11,14,17-Pentaoxa-2-azaeicosanedioic acid 1-(9H-fluoren-9-ylmethyl) ester
5,8,11,14,17-pentaoxa-2-azaeicosanoic acid 1 - (9h-fluorene-9-ylmethyl) ester
Fmoc-PEG5-OH
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azadocosan-22-oic acid
3-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid | [Molecular Formula]
C28H37NO9 | [MDL Number]
MFCD06656473 | [MOL File]
882847-32-7.mol | [Molecular Weight]
531.59 |
| Chemical Properties | Back Directory | [Boiling point ]
711.4±60.0 °C(Predicted) | [density ]
1.210±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
2-8°C | [form ]
Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Fmoc-N-amido-PEG5-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Chemical Properties]
Yellow oil | [Uses]
Fmoc-amino-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [reaction suitability]
reaction type: Pegylations | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
T&W GROUP
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021-61551611 13296011611 |
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www.trustwe.com/ |
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