| Identification | Back Directory | [Name]
Fmoc-n-amido-peg10-acid | [CAS]
2101563-45-3 | [Synonyms]
Fmoc-NH-PEG10-OH
Fmoc-NH-PEG10-acid
Fmoc-NH-PEG10-propionic acid
5,8,11,14,17,20,23,26,29,32-Decaoxa-2-azapentatriacontanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester | [Molecular Formula]
C38H57NO14 | [MDL Number]
MFCD28122954 | [MOL File]
2101563-45-3.mol | [Molecular Weight]
751.86 |
| Chemical Properties | Back Directory | [Boiling point ]
826.4±65.0 °C(Predicted) | [density ]
1.181±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
Viscous Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to off-white |
| Hazard Information | Back Directory | [Description]
Fmoc-N-amido-PEG10-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Fmoc-NH-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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T&W GROUP
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