| Identification | More | [Name]
Fmoc-L-glutamic acid 5-tert-butyl ester | [CAS]
71989-18-9 | [Synonyms]
5-tert-Butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-aminoglutarate
9-FLUORENYLMETHOXYCARBONYL-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER
FMOC-GLU(OBUT)-OH
FMOC-GLU-OTBU
FMOC-GLU(OTBU)-OH
FMOC-L-GLU(O T-BU)
FMOC-L-GLU(OTBU)-OH
FMOC-L-GLU(O-T-BUTYL)
FMOC-L-GLUTAMIC ACID 5-TERT-BUTYL ESTER
FMOC-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER
FMOC-L-GLUTAMIC ACID GAMMA-TERT-BUTYL ESTER
FMOC-L-GLUTAMIC ACID G-T-BUTYL ESTER
FMOC-L-GLUTAMIC ACID (OTBU)
FMOC-L-GLUTAMIC ACID(O-T-BUTYL)
FMOC-L-GLU(TBU)-OH
N-9-FLUORENYLMETHYLOXYCARBONYL-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER
N-9-FLUORENYLMETHYLOXYCARBONYL-L-GLUTAMIC ACID GAMMA-TERT-BUTYL ESTER
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-GAMMA-T-BUTYL-L-GLUTAMIC ACID
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-GLUTAMIC-ACID-GAMMA-T-BUTYL ESTER
N-ALPHA-FMOC-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER | [EINECS(EC#)]
276-253-8 | [Molecular Formula]
C24H27NO6 | [MDL Number]
MFCD00037135 | [Molecular Weight]
425.47 | [MOL File]
71989-18-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
83-90 °C
| [alpha ]
-4.5 º (c=1, 80% acetic acid) | [Boiling point ]
633.5±55.0 °C(Predicted) | [density ]
1.232±0.06 g/cm3(Predicted) | [refractive index ]
-4 ° (C=1, 80% AcOH) | [storage temp. ]
2-8°C
| [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
3.70±0.10(Predicted) | [color ]
White to Almost white | [Optical Rotation]
[α]20/D 5.0±2.0°, c = 1% in acetic acid: water (4:1) | [Detection Methods]
T,NMR,HPLC,Rotation | [BRN ]
3636375 | [Major Application]
peptide synthesis | [InChIKey]
OTKXCALUHMPIGM-FQEVSTJZSA-N | [SMILES]
C(O)(=O)[C@H](CCC(OC(C)(C)C)=O)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O | [CAS DataBase Reference]
71989-18-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Fmoc-L-glutamic acid 5-tert-butyl ester is a Fmoc derivative with an N-substituted tert butyl ester molecule. It is white or gray-white solid crystals at room temperature and pressure, poor solubility in water and insoluble in petroleum ether, but soluble in ethyl acetate, acetic acid and N,N-dimethylformamide. | [Chemical Properties]
White powder | [Uses]
Fmoc-Glu(OtBu)-OH (Fmoc-L-glutamic acid 5-tert-butyl ester) can be employed as a:
- Ligand in the synthesis of cis-substituted cyclopropane carboxylic acids via C-H activation of cyclopropane carboxamides using Pd catalyst.
- Linker in the preparation of multi-small molecule-conjugated PTX (paclitaxel) derivatives.
It can be also used as a building block in the preparation of stapled α-helical peptides , and peptide C-terminal thioesters . | [General Description]
The product number for this product was previously 04-12-1020.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”. | [reaction suitability]
reaction type: Fmoc solid-phase peptide synthesis |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|