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21080-31-9

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21080-31-9 Structure

21080-31-9 Structure
IdentificationBack Directory
[Name]

angoline
[CAS]

21080-31-9
[Synonyms]

angoline
6-Methoxyldihydrochelerythrine
12,13-Dihydro-1,2,13-trimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridine
[1,3]Benzodioxolo[5,6-c]phenanthridine, 12,13-dihydro-1,2,13-trimethoxy-12-methyl-
[Molecular Formula]

C22H21NO5
[MDL Number]

MFCD31557277
[MOL File]

21080-31-9.mol
[Molecular Weight]

379.41
Chemical PropertiesBack Directory
[storage temp. ]

4°C, protect from light
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

The empirical formula of this alkaloid should read C21 H21 NO5
[Uses]

Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].
[Definition]

ChEBI: Angoline is a benzophenanthridine alkaloid.
[storage]

4°C, protect from light
[References]

[1] Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91. DOI:10.1016/j.phymed.2014.04.001
Spectrum DetailBack Directory
[Spectrum Detail]

angoline(21080-31-9)1HNMR
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