| Identification | Back Directory | [Name]
BMS-1001 | [CAS]
2113650-03-4 | [Synonyms]
BMS-1001
D-Serine, N-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]-5-methylphenyl]methyl]- | [Molecular Formula]
C35H34N2O7 | [MDL Number]
MFCD32709962 | [MOL File]
2113650-03-4.mol | [Molecular Weight]
594.65 |
| Chemical Properties | Back Directory | [Boiling point ]
801.2±65.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 50 mg/mL (84.08 mM);Ethanol: Insoluble | [pka]
2.08±0.10(Predicted) | [Water Solubility ]
Water: Insoluble | [InChIKey]
UWNXGZKSIKQKAH-SSEXGKCCSA-N | [SMILES]
C(O)(=O)[C@@H](CO)NCC1=CC(C)=C(OCC2=CC=CC(C3=CC=C4OCCOC4=C3)=C2C)C=C1OCC1=CC=CC(C#N)=C1 |
| Hazard Information | Back Directory | [Uses]
BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction (IC50: 2.25 nM in a homogeneous time-resolved fluorescence binding assay). | [Biological Activity]
BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. It attenuates the inhibitory effect of soluble PD-L1 on T cell receptor-mediated T lymphocyte activation. | [target]
| Target | Value | PD-1/PD-L1
(Cell-free assay) | 253 nM(EC50) |
| [storage]
Store at -20°C |
|
| Company Name: |
Twochem Co.Ltd.
|
| Telephone: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
| Company Name: |
cjbscvictory
|
| Telephone: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|