| Identification | Back Directory | [Name]
BMS-1166 HCl | [CAS]
2113650-05-6 | [Synonyms]
BMS-1166 HCl
BMS-1166 hydrochloride
BMS1166 HCL;BMS 1166 HCL
BMS-1166 hydrochloride
(BMS1166 Hcl | [Molecular Formula]
C36H34Cl2N2O7 | [MDL Number]
MFCD32201026 | [MOL File]
2113650-05-6.mol | [Molecular Weight]
677.58 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble | [form ]
A solid | [color ]
White to off-white | [InChIKey]
HYWQPFPFYSOTHD-PVIANJOKNA-N | [SMILES]
C(N1C[C@H](O)C[C@@H]1C(=O)O)C1C=C(Cl)C(OCC2C=CC=C(C3=CC=C4OCCOC4=C3)C=2C)=CC=1OCC1C=CC=C(C#N)C=1.Cl |&1:3,6,r| |
| Hazard Information | Back Directory | [Description]
BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor. BMS-1166 binds to human PD-L1 and blocks its interaction with PD-1. BMS-1166 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. Moreover, BMS-1166 was effective in attenuating the inhibitory effect of the cell surface-associated PD-L1. | [Uses]
BMS-1166 hydrochloride is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 hydrochloride induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC50 of 1.4 nM. BMS-1166 hydrochloride antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[1][2]. | [target]
BMS-1166 hydrochloride is a potent PD-1/PD-L1 immune checkpoint inhibitor. | [References]
[1] Guzik K, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867. DOI:10.1021/acs.jmedchem.7b00293
[2] Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget. 2017 Aug 7;8(42):72167-72181. DOI:10.18632/oncotarget.20050 |
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| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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