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2242952-69-6

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2242952-69-6 Structure

2242952-69-6 Structure
IdentificationBack Directory
[Name]

BMS-986299
[CAS]

2242952-69-6
[Synonyms]

BMS-986299
[Molecular Formula]

C18H19N7O
[MOL File]

2242952-69-6.mol
[Molecular Weight]

349.39
Chemical PropertiesBack Directory
[Boiling point ]

757.5±60.0 °C(Predicted)
[density ]

1.407±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: Slightly soluble: 0.1-1 mg/ml
Ethanol: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
[form ]

Solid
[pka]

11.46±0.40(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

BMS-986299 (compound 112) is a first-in-class NLRP3 inflammasome agonist with an EC50 of 1.28 μM. (patent WO2018152396A1).
[IC 50]

NLRP3: 1.28 μM (EC50)
[References]

[1] Gary Glick, et al. Substituted imidazo-quinolines as nlrp3 modulators. WO2018152396A1.
[2] Gao G, et al., Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro. Front Pharmacol. 2022 Jul 5;13:906548. DOI:10.3389/fphar.2022.906548
Spectrum DetailBack Directory
[Spectrum Detail]

BMS-986299(2242952-69-6)1HNMR
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