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2131798-13-3

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2131798-13-3 Structure

2131798-13-3 Structure
IdentificationBack Directory
[Name]

GSK-656
[CAS]

2131798-13-3
[Synonyms]

GSK-656
GSK656 HCl
GSK-3036656
GSK656,GSK-656
GSK656 HCl (GSK3036656, GSK070)
[Molecular Formula]

C10H14BCl2NO4
[MDL Number]

MFCD31657361
[MOL File]

2131798-13-3.mol
[Molecular Weight]

293.94
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO:67.5(Max Conc. mg/mL);229.64(Max Conc. mM)
[form ]

Solid
[color ]

Off-white to light yellow
Safety DataBack Directory
[Symbol(GHS) ]

Health Hazard (GHS08)Skull and Crossbones (GHS06)
GHS08,GHS06
[Signal word ]

Danger
[Hazard statements ]

H373-H301
[Precautionary statements ]

P260-P314-P501-P264-P270-P301+P310-P321-P330-P405-P501
Hazard InformationBack Directory
[Uses]

Ganfeborole hydrochloride (GSK656) is a potent antitubercular agent, acting as an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS), with an IC50 of 0.2 μM.
[in vivo]

Ganfeborole hydrochloride shows potent antitubercular activity in mice infected with M. tuberculosis H37Rv, with ED99 of 0.4 mg/kg[1].

[References]

[1] Li X, et al. Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656). J Med Chem. 2017 Oct 12;60(19):8011-8026. DOI:10.1021/acs.jmedchem.7b00631
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