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2140807-05-0

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2140807-05-0 Structure

2140807-05-0 Structure
IdentificationBack Directory
[Name]

2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide
[CAS]

2140807-05-0
[Synonyms]

CPD3616
JBJ-04-125-02
(Rac)-JBJ-04-125-02
2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide
2H-Isoindole-2-acetamide, α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-6-[4-(1-piperazinyl)phenyl]-N-2-thiazolyl-
[Molecular Formula]

C29H26FN5O3S
[MOL File]

2140807-05-0.mol
[Molecular Weight]

543.61
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

(Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor[1].
[IC 50]

EGFR (L858R/T790M): 0.26 nM (IC50)
[References]

[1] To C, et al. Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor. Cancer Discov. 2019 Jul;9(7):926-943. DOI:10.1158/2159-8290.CD-18-0903
Spectrum DetailBack Directory
[Spectrum Detail]

2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide(2140807-05-0)1HNMR
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