Identification | Back Directory | [Name]
CPD2206 | [CAS]
2152628-33-4 | [Synonyms]
CPD2206 LOX-292 LOXO-292 SELPERCATINIB LOXO-292 USP/EP/BP Inhibitor LOXO-292 LOXO-292,Selpercatinib Selpercatinib(LOXO-292) LOXO-292; LOXO292;LOXO 292 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]pyridin-3-yl]pyrazolo[1,5-a]pyridine-3-carbonitrile Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-3-pyridinyl]- 6-?(2-?Hydroxy-?2-?methylpropoxy)?-?4-?[6-?[6-?[(6-?methoxy-?3-?pyridinyl)?methyl]?-?3,?6-?diazabicyclo[3.1.1]?hept-?3-?yl]?-?3-?pyridinyl]?pyrazolo[1,?5-?a]?pyridine-?3-?carbonitrile | [EINECS(EC#)]
207-854-9 | [Molecular Formula]
C29H31N7O3 | [MDL Number]
MFCD31814089 | [MOL File]
2152628-33-4.mol | [Molecular Weight]
525.6 |
Chemical Properties | Back Directory | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:20.0(Max Conc. mg/mL);38.05(Max Conc. mM) | [form ]
A crystalline solid | [pka]
14.00±0.29(Predicted) | [InChIKey]
XIIOFHFUYBLOLW-UHFFFAOYSA-N | [SMILES]
C12=C(C#N)C=NN1C=C(OCC(O)(C)C)C=C2C1=CC=C(N2CC3CC(N3CC3=CC=C(OC)N=C3)C2)N=C1 |
Hazard Information | Back Directory | [Uses]
Selpercatinib is a small molecule protein kinase inhibitor which may be used in the treatment of cancer. | [Side effects]
Selpercatinib can cause serious side effects including liver toxicity, high blood pressure, heart rhythm changes due to prolongation of heart electrical activity (QT prolongation), bleeding, allergic reactions, impaired wound healing and harm to an unborn baby.
Selpercatinib may cause harm to a developing fetus or a newborn baby. | [storage]
Store at -20°C | [Dosage]
The recommended selpercatinib dose based on body weight is:
(1) Less than 50 kg: 120 mg orally twice daily
(2) 50 kg or greater: 160 mg orally twice daily
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