| Identification | More | [Name]
4-(4-Methylpiperazino)benzylamine | [CAS]
216144-45-5 | [Synonyms]
4-(4-METHYLPIPERAZINO)BENZYLAMINE
AKOS B022037
ART-CHEM-BB B022037
BUTTPARK 98\50-54
4-(4-Methyl-1-piperazinyl)benzylamine
4-(4-Methylpiperazin-1-yl)benzylamine
4-(4-Methylpiperazin-1-yl)Benz
4-(4-Methylpiperazino)benzylam
4-(4-Methylpiperazino)benzylamine 90%
4-(4-Methylpiperazino)benzylamine90%
4-(4-Methylpiperazin-1-yl)benzylamine 90%
(4-(4-methylpiperazin-1-yl)phenyl)methanamine | [Molecular Formula]
C12H19N3 | [MDL Number]
MFCD03086117 | [Molecular Weight]
205.3 | [MOL File]
216144-45-5.mol |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319 | [Precautionary statements ]
P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | [Hazard Codes ]
C | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [Hazard Note ]
Corrosive | [HS Code ]
2933599590 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-(4-methyl-1-piperazinyl)benzylamine from 4-(4-methylpiperazin-1-yl)benzonitrile: Sodium borohydride (10 eq.) was added to a solution of 4-(4-methylpiperazin-1-yl)benzonitrile (1 eq.) and cobalt chloride hexahydrate (2.1 eq.). The reaction mixture was stirred for 5 hours and then filtered through a pad of diatomaceous earth. The organic phase was concentrated under reduced pressure. The yellow oil obtained was purified by rapid chromatography on silica gel (dichloromethane: methanol = 8:2) to afford the target compound 4-(4-methyl-1-piperazinyl)benzylamine as a white solid in 50% yield.1H NMR (400 MHz, methanol-d4): δ (ppm) 2.42 (s, 3H); 2.74 (t, J=8Hz, 4H); 3.17 (t. J=8Hz, 4H); 4.43 (s, 2H); 6.89 (d, J=8Hz, 2H); 7.18 (d, J=8Hz, 2H). Elemental analysis (C12H19N3) calculated values: C, 70.20; H, 9.33; N, 20.47; measured values: C, 70.10; H, 9.13; N, 20.27. | [References]
[1] Tetrahedron Letters, 2013, vol. 54, # 38, p. 5204 - 5206
[2] Journal of Medicinal Chemistry, 2005, vol. 48, # 26, p. 8261 - 8269
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 12, p. 5293 - 5305
[4] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 7, p. 741 - 745 |
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