| Identification | More | [Name]
Benzylamine | [CAS]
100-46-9 | [Synonyms]
A-AMINOTOLUENE
AKOS BBS-00003631
ALPHA-AMINOTOLUENE
BENZENEMETHANAMINE
BENZENMETHANAMINE
BENZYLAMINE
BZA
HISTOPREP FROZEN TISSUE EMBEDDING MEDIA
LABOTEST-BB LTBB000422
N-BENZYLAMINE
PHENYLMETHYLAMINE
RARECHEM AL BW 0006
TISSUEPREP EMBEDDING MEDIA
(aminomethyl)benzene
(phenylmethyl)amine[qr]
alpha-aminotoluene[qr]
Aminotoluene
-Aminotoluene
aminotoluene[qr]
benzenemethanamine[qr] | [EINECS(EC#)]
202-854-1 | [Molecular Formula]
C7H9N | [MDL Number]
MFCD00212756 | [Molecular Weight]
107.15 | [MOL File]
100-46-9.mol |
| Chemical Properties | Back Directory | [Appearance]
colourless liquid with an ammoniacal odour | [Melting point ]
10 °C (lit.) | [Boiling point ]
184-185 °C (lit.) | [density ]
0.981 g/mL at 25 °C(lit.)
| [vapor pressure ]
1.2 hPa (20 °C) | [refractive index ]
n20/D 1.543(lit.)
| [Fp ]
140 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
alcohol: miscible | [form ]
Liquid | [pka]
9.33(at 25℃) | [color ]
Clear colorless to slightly yellow | [Odor]
Strong ammonia. | [PH]
11.4 (100g/l, H2O, 20℃) | [Stability:]
Combustible. Incompatible with strong oxidizing agents, strong acids. | [explosive limit]
0.7-8.2%(V) | [Water Solubility ]
soluble | [Specific Heat Capacity]
Cp(liquid):207.2J/(g·K),at 25℃ | [Sensitive ]
Air Sensitive | [Merck ]
14,1125 | [BRN ]
741984 | [Henry's Law Constant]
7.1×10-1 mol/(m3Pa) at 25℃, Yao et al. (2002) | [Dielectric constant]
4.6（Ambient） | [InChI]
1S/C7H9N/c8-6-7-4-2-1-3-5-7/h1-5H,6,8H2 | [InChIKey]
WGQKYBSKWIADBV-UHFFFAOYSA-N | [SMILES]
NCc1ccccc1 | [LogP]
1 at 25℃ | [Surface tension]
37.1mN/m at 293.15K | [Uses]
Chemical intermediate for dyes, pharmaceuticals, and polymers. | [CAS DataBase Reference]
100-46-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzylamine(100-46-9) | [EPA Substance Registry System]
100-46-9(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H302+H312-H314 | [Precautionary statements ]
P270-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 | [Hazard Codes ]
C | [Risk Statements ]
R21/22:Harmful in contact with skin and if swallowed .
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2735 8/PG 2
| [WGK Germany ]
1
| [RTECS ]
DP1488500
| [F ]
34 | [Autoignition Temperature]
405 °C | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29214900 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Oral
Eye Dam. 1
Skin Corr. 1B | [Hazardous Substances Data]
100-46-9(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 552 mg/kg LD50 dermal Rat 1350 mg/kg |
| Hazard Information | Back Directory | [General Description]
Colorless to light yellow liquid with a strong odor of ammonia. Floats and mixes with water. | [Reactivity Profile]
In presence of moisture, BENZYLAMINE(100-46-9) may weakly corrode some metals. Liquid will attack some plastics [USCG, 1999]. Neutralize acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. | [Air & Water Reactions]
Water soluble. | [Hazard]
Highly toxic, strong irritant to skin and mucous membranes. | [Health Hazard]
Inhalation of vapor causes irritation of the mucous membranes of the nose and throat, and lung irritation with respiratory distress and cough. Headache, nausea, faintness, and anxiety can occur. Exposure to vapor produces eye irritation with lachrymation, conjunctivitis, and corneal edema resulting in halos around lights. Direct local contact with liquid is known to produce severe and sometimes permanent eye damage and skin burns. Vapors may also produce primary skin irritation and dermatitis. | [Fire Hazard]
Special Hazards of Combustion Products: Toxic nitrogen oxides may form in a fire. | [Chemical Properties]
colourless liquid with an ammoniacal odour | [Definition]
ChEBI: A primary amine compound having benzyl as the N-substituent. It has been isolated from Moringa oleifera (horseradish tree). | [Preparation]
28% Aqueous Ammonia, 810g
Benzyl chloride, 84.3g
49% Aqueous NaOH, 52.3g
Diethyl Ether, 200g
A three-necked flask was equipped with a reflux condenser dropping funnel and an agitator. All of the aqueous ammonium hydroxide solution was poured into the flask, then the benzyl chloride was introduced drop by drop; over a period of two hours with constant stirring of the mixture. The exothermic heat of reaction kept the temperature between 30-34°C during this period. When it is desired to introduce the benzyl chloride at a faster rate, conventional cooling means can be employed to control the temperature. A large excess of ammonia was employed as the molar ratio of reactants was 20:1. An additional two hours was allowed to insure completion of the following reaction:
Then the equimolecular quantity of caustic soda solution was added. When quiescent, the mixture split into an aqueous layer and an oily layer. After separating these two layers by use of a separatory funnel, the aqueous phase was made available for further repeated use by merely adding sufficient ammonium hydroxide to bring the total quantity of ammonia up to the original figure. The oily layer was steam distilled until no further oily constituent was visible in the condensed distillate as it dripped down the condenser tube. This distillate was saturated with sodium chloride and successively extracted with an initial 80 and three 40 gram batches of ethyl ether. Upon evaporation of the ether from the extract, 52g of crude benzylamine remain which was distilled at atmospheric pressure. 41g grams of substantially pure benzylamine distilled over in the boiling range 185-192°C, while the residue was found to contain an additional 2.3g of benzylamine and 8.7g of other matter which was believed to consist entirely of dibenzyl amine. Thus the total yield of benzylamine was 43.3g or 60.7% based on the weight of benzyl chloride.
| [Synthesis Reference(s)]
Synthetic Communications, 25, p. 863, 1995 DOI: 10.1080/00397919508013422
Synthesis, p. 48, 1987 DOI: 10.1055/s-1987-27838 | [Flammability and Explosibility]
Nonflammable(100%) | [Chemical Reactivity]
Reactivity with Water: No reaction; Reactivity with Common Materials: In presence of moisture may severely corrode some metals. In liquid state this chemical will attack some plastics; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent. | [Toxicology]
Benzylamine is readily biodegradable. It is harmful in aquatic environment [German class for hazards in aquatic environment: 1 (weak effect) (WGK 1)].Acute toxicity: Pseudomonas fluorescens (bacteria) 500 mg (EC0); Scenedesmus quadricauda (algae) 6 mg (96-h EC10); Daphnia magna 60 mg (48-h EC50); Leuciscus idus (fish) 20 mg (48-h EC0); Pimephals promelas (fish) 102 mg (96-h EC50).Benzylamine is Ames test negative (no mutagenic effect). Acute oral toxicity: LD50 1130 mg/kg (rat). Acute percutaneous toxicity: LD50 1340 mg/kg (rat). Toxicity class 3 (Switzerland). All rats inhaling benzylamine for 3 h survived a two-week period (full body exposure). After full body exposure for 5h, 17 % died. | [storage]
Benzylamine is slowly oxidized on contact with air and forms benzalbenzylamine. It also reacts with carbon dioxide to form its solid carbamic acid salt. It therefore should be stored in a tight closed container for not more than one year. For longer storage, a nitrogen blanket is recommended. In Germany the conditions for storage are classified as 8L (VCI-Lagerklasse).
| [Purification Methods]
Dry it with NaOH or KOH, then distil it under N2, through a column packed with glass helices, taking the middle fraction. Also distil it from zinc dust under reduced pressure. The picrate has m 196o (from EtOH), and the p-toluenesulfonamide has m 116o (from MeOH). [Beilstein 12 IV 2155.] | [Toxics Screening Level]
The ITSL for benzylamine has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on an annual averaging time. |
|
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|