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2163060-83-9

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2163060-83-9 Structure

2163060-83-9 Structure
IdentificationBack Directory
[Name]

WY-135
[CAS]

2163060-83-9
[Synonyms]

WY-135
WY135,WY 135
2,4-Pyrimidinediamine, 5-chloro-N2-[2-methoxy-4-[4-[(4-methyl-1-piperazinyl)methyl]-1H-1,2,3-triazol-1-yl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-
[Molecular Formula]

C28H34ClN9O3S
[MDL Number]

MFCD31813638
[MOL File]

2163060-83-9.mol
[Molecular Weight]

612.15
Chemical PropertiesBack Directory
[Boiling point ]

797.5±70.0 °C(Predicted)
[density ]

1.41±0.1 g/cm3(Predicted)
[pka]

7.42±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

WY-135 is an ALK (IC50=1.4 nM) and ROS1 (IC50=1.1 nM) dual inhibitor.
[References]

[1] Wang Y, et al. Discovery of novel 2,4-diarylaminopyrimidine analogues as ALK and ROS1 dual inhibitors to overcome crizotinib-resistant mutants including G1202R. Eur J Med Chem. 2018 Jan 1;143:123-136. DOI:10.1016/j.ejmech.2017.11.008
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