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2163772-16-3

2163772-16-3 Structure

2163772-16-3 Structure
IdentificationBack Directory
[Name]

4,7,10-Trioxa-13-azaheptadecanoic acid, 17-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-14,17-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
[CAS]

2163772-16-3
[Synonyms]

DBCO-PEG3-NHS ester
4,7,10-Trioxa-13-azaheptadecanoic acid, 17-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-14,17-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
[Molecular Formula]

C32H35N3O9
[MOL File]

2163772-16-3.mol
[Molecular Weight]

605.64
Chemical PropertiesBack Directory
[density ]

1.35±0.1 g/cm3(Predicted)
[form ]

Solid-Liquid Mixture
[pka]

15.14±0.46(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

DBCO-PEG3-NHS ester (cpmpd 45) is a ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
[References]

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Shih-Hsien Chuang, et al. Antibody-drug conjugates containing an anti-mesothelin antibody and uses thereof. Patent. WO2021248048.
Spectrum DetailBack Directory
[Spectrum Detail]

4,7,10-Trioxa-13-azaheptadecanoic acid, 17-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-14,17-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester(2163772-16-3)1HNMR
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