ChemicalBook--->CAS DataBase List--->217480-26-7

217480-26-7

217480-26-7 Structure

217480-26-7 Structure
IdentificationBack Directory
[Name]

L-803,087 TRIFLUOROACETATE
[CAS]

217480-26-7
[Synonyms]

L-803,087 TRIFLUOROACETATE
L-Arginine, N2-[4-(5,7-difluoro-2-phenyl-1H-indol-3-yl)-1-oxobutyl]-, methyl ester
N2-[4-(5,7-DIFLUORO-2-PHENYL-1H-INDOL-3-YL)-1-OXOBUTYL]-L-ARGININE METHYL ESTER TRIFLUOROACETATE
[Molecular Formula]

C25H29F2N5O3
[MDL Number]

MFCD09037334
[MOL File]

217480-26-7.mol
[Molecular Weight]

485.53
Chemical PropertiesBack Directory
[density ]

1.33±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble to 100 mM in DMSO and to 100 mM in ethanol
[form ]

Powder
[pka]

14.54±0.46(Predicted)
[color ]

White to light yellow
Hazard InformationBack Directory
[Uses]

Somatostatin receptors are often overexpressed in tumours and are potential therapeutic targets. Somatostatin receptor agonists can be used to study signaling pathways related somatostatin receptor. L 803087 is a somatostatin sst4 receptor agonist.
[Biological Activity]

Potent and selective somatostatin sst 4 receptor agonist. K i values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst 4 , sst 1 , sst 2 , sst 3 and sst 5 receptors respectively. Facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice in vivo .
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