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1786412-46-1

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1786412-46-1 Structure

1786412-46-1 Structure
IdentificationBack Directory
[Name]

N2-[4-(5,7-DIFLUORO-2-PHENYL-1H-INDOL-3-YL)-1-OXOBUTYL]-L-ARGININE METHYL ESTER TRIFLUOROACETATE
[CAS]

1786412-46-1
[Synonyms]

L-803087 TFA
[Molecular Formula]

C27H30F5N5O5
[MDL Number]

MFCD09037334
[MOL File]

1786412-46-1.mol
[Molecular Weight]

599.55
Hazard InformationBack Directory
[Uses]

L-803087 TFA is a potent and selective somatostatin sst4 receptor agonist with a Ki of 0.7 nM. L-803087 TFA is >280-fold more selective for sst4 receptor than other somatostatin receptors. L-803087 TFA facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice[1][2].
[in vivo]

L-803087 (5 nmol) is doubled seizure activity in wild-type mice on average. Interestingly, this effect is blocked by 3 nmol Octreotide. In hippocampal slices from wild-type mice, Octreotide (2 μM) does not modify AMPA-mediated synaptic responses while facilitation occurred with L-803087 (2 μM)[2].

[References]

[1] Rohrer SP, et al. Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science. 1998 Oct 23;282(5389):737-40. DOI:10.1126/science.282.5389.737
[2] Moneta D, et al. Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice. Eur J Neurosci. 2002 Sep;16(5):843-9. DOI:10.1046/j.1460-9568.2002.02146.x
1786412-46-1 suppliers list
Company Name: Biosynth Biological Technology (Suzhou) Co Ltd  
Telephone: 51288865780
Website: www.biosynth.com
Company Name: Biorbyt Ltd.  
Telephone: +44 (0)1223 859 353
Website: http://www.biorbyt.com
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1786412-46-1 217480-26-7 396091-73-9 2378114-72-6 73032-94-7 84211-54-1