| Identification | More | [Name]
2-Chloro-4-fluorobenzoyl chloride | [CAS]
21900-54-9 | [Synonyms]
2-CHLORO-4-FLUOROBENZENE-1-CARBONYL CHLORIDE
2-CHLORO-4-FLUOROBENZOYL CHLORIDE
Benzoyl chloride, 2-chloro-4-fluoro-(8CI,9CI)
2-Chloro-4-fluorobenzoyl chloride 98%
2-Chloro-4-fluorobenzoylchloride98% | [EINECS(EC#)]
623-229-3 | [Molecular Formula]
C7H3Cl2FO | [MDL Number]
MFCD00084954 | [Molecular Weight]
193 | [MOL File]
21900-54-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear pale yellow to yellow liquid | [Melting point ]
16 °C | [Boiling point ]
98-102 °C (15 mmHg) | [density ]
1.447 g/mL at 25 °C | [refractive index ]
1.549-1.551
| [Fp ]
82-84°C/15mm | [form ]
powder to lump to clear liquid | [color ]
White or Colorless to Light yellow | [Sensitive ]
Moisture Sensitive | [BRN ]
2254071 | [InChI]
InChI=1S/C7H3Cl2FO/c8-6-3-4(10)1-2-5(6)7(9)11/h1-3H | [InChIKey]
POIAZJJVWRVLBO-UHFFFAOYSA-N | [SMILES]
C(Cl)(=O)C1=CC=C(F)C=C1Cl | [CAS DataBase Reference]
21900-54-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns.
R29:Contact with water liberates toxic gas.
R22:Harmful if swallowed. | [Safety Statements ]
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
3265 | [WGK Germany ]
3 | [Hazard Note ]
Corrosive | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29163990 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Skin Corr. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
Clear pale yellow to yellow liquid | [Uses]
2-Chloro-4-fluorobenzoyl chloride serves as the acyl chloride precursor for 2-chloro-4-fluorobenzophenone, reacting with benzene under AlCl3 at 0–5 °C, and for ethyl 2-(2-chloro-4-fluorobenzoyl)-3-(dimethylamino)acrylate, obtained with ethyl 3-(dimethylamino)acrylate and TEA in anhydrous dioxane under reflux[1-2]. | [References]
[1]
Zhang, C., Wang, Z. Y. (1993). Poly(arylene ethers) containing 2,2'-dibenzoylbiphenyl units from isomeric 2-chlorofluorobenzophenones. Macromolecules, 26(13), 3324–3329. https://doi.org/10.1021/ma00065a013
[2]
Neto, R., Domingues, L., Jesus, A. R. (2026). Synthesis of Fluoroquinolones: Revisiting the Grohe Route in DES-Based Media. Pharmaceuticals, 19(2), 208. https://doi.org/10.3390/ph19020208
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