| Identification | Back Directory | [Name]
Z-VDVAD-AFC | [CAS]
219138-08-6 | [Synonyms]
Z-VDVAD-AFC
Z-Val-Asp-Ala-Asp-AFC
Z-VDVAD-AFC USP/EP/BP
Z-VAL-ASP-VAL-ALA-ASP-AFC
CASPASE-2 SUBSTRATE I, FLUOROGENIC
L-α-Asparagine,N-[(phenylmethoxy)carbonyl]-L-valyl-L-α-aspartyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-
N-[(Phenylmethoxy)carbonyl]-L-valyl-L-alpha-aspartyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-alpha-asparagine
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-3-carboxy-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxo-4-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]butanoic acid | [Molecular Formula]
C39H45F3N6O13 | [MDL Number]
MFCD01318834 | [MOL File]
219138-08-6.mol | [Molecular Weight]
862.8 |
| Chemical Properties | Back Directory | [Boiling point ]
1153.6±65.0 °C(Predicted) | [density ]
1.399±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [pka]
4.09±0.10(Predicted) | [Sequence]
{Z}-Val-Asp-Val-Ala-Asp-{AFC} |
| Hazard Information | Back Directory | [Uses]
Z-VDVAD-AFC is a fluorogenic substrate. Z-VDVAD-AFC is used to measure the activity of cysteine protease 3 (Caspase-3). Z-VDVAD-AFC undergoes hydrolysis to release 7-amino-4-trifluoromethylcoumarin (AFC). AFC is fluorescent under ultraviolet light and can emit fluorescent signals[1]. | [References]
[1] Pallepati P, et, al. Mild thermotolerance induced at 40°C protects HeLa cells against activation of death receptor-mediated apoptosis by hydrogen peroxide. Free Radic Biol Med. 2011 Mar 15;50(6):667-79. DOI:10.1016/j.freeradbiomed.2010.11.022 |
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