ChemicalBook--->CAS DataBase List--->21962-45-8

21962-45-8

Request For Quotation
21962-45-8 Structure

21962-45-8 Structure
IdentificationBack Directory
[Name]

4-CYANO-2-METHOXYBENZALDEHYDE
[CAS]

21962-45-8
[Synonyms]

4-CYANO-2-METHOXYBENZALDEHYDE
4-Cyaon-2-methoxybenzaldehyde
2-Methoxy-4-cyanobenzaldehyde
4-forMyl-3-Methoxybenzonitrile
Benzonitrile, 4-formyl-3-methoxy-
4-ForMyl-3-Methoxybenzonitrile(2-Methoxy-4-cyanobenzaldehyde)
[EINECS(EC#)]

804-777-4
[Molecular Formula]

C9H7NO2
[MDL Number]

MFCD07779491
[MOL File]

21962-45-8.mol
[Molecular Weight]

161.16
Chemical PropertiesBack Directory
[Melting point ]

109-111℃
[Boiling point ]

318℃
[density ]

1.18
[vapor pressure ]

0.003-2.3Pa at 20-80℃
[Fp ]

138℃
[storage temp. ]

Inert atmosphere,2-8°C
[Appearance]

Off-white to light yellow Solid
[InChI]

InChI=1S/C9H7NO2/c1-12-9-4-7(5-10)2-3-8(9)6-11/h2-4,6H,1H3
[InChIKey]

ZXENVSJZOHXCKL-UHFFFAOYSA-N
[SMILES]

C(#N)C1=CC=C(C=O)C(OC)=C1
[LogP]

1.42 at 20℃ and pH7
Safety DataBack Directory
[Symbol(GHS) ]

Corrosion (GHS05)
GHS05
[Signal word ]

Danger
[Hazard statements ]

H318
[Precautionary statements ]

P280-P305+P351+P338
[Hazard Codes ]

Xi
[Risk Statements ]

43
[Safety Statements ]

36/37
[REACH Registrations]

Active
[HS Code ]

2926907090
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Benzonitrile, 4-(hydroxymethyl)-3-methoxy--->Benzoyl chloride, 4-cyano-2-methoxy- (9CI)-->Benzoyl chloride, 3-methoxy-4-methyl- (9CI)-->3-Methoxy-4-methylbenzoic acid-->4-DibroMoMethyl-3-Methoxybenzonitrile-->4-Bromo-2-hydroxybenzoic acid-->3-Iodophenol-->2-Hydroxy-4-iodo-benzaldehyde-->3-Methoxy-4-methylbenzonitrile-->4-Iodo-2-methoxybenzaldehyde-->4-Hydroxy-3-methoxybenzonitrile-->4-bromo-2-methoxybenzaldehyde-->Methyl 4-bromo-2-methoxybenzoate 98
[Preparation Products]

Benzonitrile, 4-formyl-3-hydroxy-
Hazard InformationBack Directory
[Uses]

4-formyl-3-methoxybenzonitrile is a Finerenone intermediate compound. Finerenone is a non-steroidal salicorticosteroid receptor antagonist used to reduce the risk of serious kidney and heart problems in patients with chronic kidney disease associated with type 2 diabetes.
[Synthesis]

79 g (370 mmol) of sodium metaperiodate are added in portions to a vigorously stirred solution of 48 g (185 mmol) of tert-butyl (2E)-3-(4-cyano-2-methoxyphenyl)acrylate, 207 mg (0.81 mmol) of osmium tetroxide and 1.4 g (6.14 mmol) of benzyltriethylammonium chloride in 750 ml of water/THF (2:1), keeping the reaction temperature below 30° C. The solution is stirred at RT for a further 1 h. Water (2000 ml) is added, and the mixture is filtered. The remaining solid is dissolved in ethyl acetate and washed with a saturated sodium chloride solution. The organic phase is dried over magnesium sulfate and concentrated. The residue is stirred with petroleum ether. 21.18 g (71% of theory) of 4-cyano-2-methoxybenzaldehyde is obtained as a white solid.
4-CYANO-2-METHOXYBENZALDEHYDE
[References]

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 10, p. 2468 - 2485
[2] Patent: EP1719767, 2006, A1. Location in patent: Page/Page column 24-26; 28; 33
Spectrum DetailBack Directory
[Spectrum Detail]

4-formyl-3-methoxybenzonitrile(21962-45-8)1HNMR
21962-45-8 suppliers list
Company Name: Nanjing Vcare PharmaTech Co., Ltd  Gold
Telephone: 025-58741518 13327700685
Website: http://www.vcarepharmatech.com
Company Name: Changzhou Ansciep Chemical Co., Ltd.  Gold
Telephone: 0519-86305871
Website: www.ansciepchem.com/
Company Name: Shanghai Qitong Pharmaceutical Technology Co., Ltd.  Gold
Telephone: 18918399319
Website: https://www.chemicalbook.com/ShowSupplierProductsList646180/0_EN.htm
Company Name: Hangzhou Chemtrue Bio-Tech Co.,Ltd.  Gold
Telephone: 19967494293
Website: www.chemtrue-bio.com
Company Name: Jinan XuanDe Chemical Co., Ltd.  Gold
Telephone: 0531-88803958 19862127196
Website: http://www.shiningpharm.com/
Company Name: YANGZHOU HENGCHUAN CHEMICAL CO., LTD.  Gold
Telephone: 13775575144
Website: http://www.chinaeastchem.com
Company Name: Jiangsu Haici Biopharmaceutical Co., Ltd.  Gold
Telephone: 15722465851 15722465851
Website:
Company Name: Chongqing Sennod Medical Co., Ltd  Gold
Telephone: 15086900926
Website:
Company Name: Shanghai Bosihuike Pharmaceutical Technology Co., Ltd  Gold
Telephone: 18049730290 18049730290;
Website: https://www.bshkpharma.com
Company Name: Beijing HwrkChemical Technology Co., Ltd  
Telephone: 89508211 18501085097
Website: www.hwrkchemical.com
Company Name: Energy Chemical  
Telephone: 400-0056266
Website: www.energy-chemical.com
Company Name: Capot Chemical Co., Ltd  
Telephone: +86 (0) 571 85 58 67 18
Website: www.capotchem.com
Company Name: Changzhou Huanling Chemical Co., Ltd.  
Telephone: 89803005 18206112582
Website: http://www.huanlingchem.com
Company Name: Jia Xing Isenchem Co.,Ltd  
Telephone: 0573-85285100 18627885956
Website: https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm
Company Name: Accela ChemBio Co.,Ltd.  
Telephone: 021-50795510 4000665055
Website: http://www.shao-yuan.com/
Company Name: Shanghai Longsheng chemical Co.,Ltd.  
Telephone: 58099637 13585536065
Website: www.shlshg.com
Company Name: Shanghai Hanhong Scientific Co.,Ltd.  
Telephone: 021-54306202 13764082696
Website: https://www.hanhongsci.com
Company Name: Jinan Chenghui Shuangda biological Co., LTD  
Telephone: 053158897070 15550412551
Website: www.jnchsd.com
Tags:21962-45-8 Related Product Information
1256345-67-1 939-97-9 3556-60-3