| Identification | Back Directory | [Name]
Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]- | [CAS]
2225836-30-4 | [Synonyms]
ACH-000143
Acetamide, N-[2-(5-chloro-2,6-dimethoxy-1H-benzimidazol-1-yl)ethyl]- | [Molecular Formula]
C13H16ClN3O3 | [MDL Number]
MFCD34167540 | [MOL File]
2225836-30-4.mol | [Molecular Weight]
297.74 |
| Chemical Properties | Back Directory | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 50 mg/mL (167.93 mM; Need ultrasonic) | [form ]
Solid | [pka]
15.77±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively[1]. | [Biological Activity]
ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively[1].
ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats[1].ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate[1].ACH-000143 significantly reduces plasma glucose at 10 mg/kg (-16.4%, p < 0.05) and 30 mg/kg (-16.9%, p < 0.01)[1]. | [in vivo]
ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats[1].
ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate[1].
ACH-000143 significantly reduces plasma glucose at 10 mg/kg (?16.4%, p < 0.05) and 30 mg/kg (?16.9%, p < 0.01)[1].
| Animal Model: | High-fat diet rats[1]. | | Dosage: | 10 and 30 mg/kg. | | Administration: | Orally, once daily for two months. | | Result: | Significantly reduced the weekly BW gain on weeks. |
| [IC 50]
MT1: 0.06 nM (EC50); MT2: 0.32 nM (EC50) | [References]
[1]. Marcos Antonio Ferreira Jr, et al. Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats. J Med Chem. 2021 Feb 25;64(4):1904-1929. |
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| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|