| Identification | Back Directory | [Name]
Pyrazolo[1,5-a]quinazoline-3-carbonitrile, 2-[1-(4-chlorophenyl)cyclopropyl]-4,5-dihydro-7-iodo-5-oxo- | [CAS]
2226517-75-3 | [Synonyms]
Pyrazolo[1,5-a]quinazoline-3-carbonitrile, 2-[1-(4-chlorophenyl)cyclopropyl]-4,5-dihydro-7-iodo-5-oxo- | [Molecular Formula]
C20H12ClIN4O | [MOL File]
2226517-75-3.mol | [Molecular Weight]
486.69 |
| Chemical Properties | Back Directory | [Boiling point ]
551.3±50.0 °C(Predicted) | [density ]
1.88±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO|9.73|20| | [form ]
Solid | [pka]
10.96±0.20(Predicted) | [color ]
White to off-white | [InChI]
1S/C20H12ClIN4O/c21-12-3-1-11(2-4-12)20(7-8-20)17-15(10-23)18-24-19(27)14-9-13(22)5-6-16(14)26(18)25-17/h1-6,9H,7-8H2,(H,24,27) | [InChIKey]
VABPBCMFKJDOHP-UHFFFAOYSA-N | [SMILES]
IC1=CC=C(N2C(NC3=O)=C(C#N)C(C4(CC4)C5=CC=C(Cl)C=C5)=N2)C3=C1 |
| Hazard Information | Back Directory | [Description]
Dynapyrazole A is a hedgehog signaling inhibitor and dynein inhibitor. | [Uses]
Dynapyrazole A is a specific inhibitor of microtubule dynamin that specifically inhibits the ATPase activity of microtubule-stimulated dynamin without blocking microtubule-independent basal activity[1]. | [storage]
Store at -20°C | [References]
[1] Zhaoyang Jing, et al. Rotavirus Viroplasm Biogenesis Involves Microtubule-Based Dynein Transport Mediated by an Interaction between NSP2 and Dynein Intermediate Chain. J Virol. 2021 Oct 13;95(21):e0124621. DOI:10.1128/JVI.01246-21 |
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Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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